Guo Zhen Fan1,2, Rui Xue Li2, Qi Jiang2, Man Man Niu2, Zhen Qiu2, Wei Xia Chen2, Hui Hui Liu2, Jin Wei Ruan2, Peng Hu3,4. 1. Department of Pediatrics, Chaohu Hospital of Anhui Medical University, No.64 Chaohu North Road, Hefei, 230022, People's Republic of China. 2. Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, No. 218 Ji-Xi Road, Hefei, 230022, People's Republic of China. 3. Department of Pediatrics, Chaohu Hospital of Anhui Medical University, No.64 Chaohu North Road, Hefei, 230022, People's Republic of China. hupeng28@aliyun.com. 4. Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, No. 218 Ji-Xi Road, Hefei, 230022, People's Republic of China. hupeng28@aliyun.com.
Abstract
BACKGROUND: The present study focuses on the associations of streptococcal infection with the clinical phenotypes, relapse/recurrence and renal involvement in Henoch-Schönlein purpura (HSP) children. METHODS: Two thousand seventy-four Chinese children with HSP were recruited from January 2015 to December 2019. Patients' histories associated with HSP onset were obtained by interviews and questionnaires. Laboratory data of urine tests, blood sample and infectious agents were collected. Renal biopsy was performed by the percutaneous technique. RESULTS: (1) Streptococcal infection was identified in 393 (18.9%) HSP patients, and served as the most frequent infectious trigger. (2) Among the 393 cases with streptococcal infection, 43.0% of them had arthritis/arthralgia, 32.1% had abdominal pain and 29.3% had renal involvement. (3) 26.1% of HSP patients relapsed or recurred more than 1 time within a 5-year observational period, and the relapse/recurrence rate in streptococcal infectious group was subjected to a 0.4-fold decrease as compared with the non-infectious group. (4) No significant differences in renal pathological damage were identified among the streptococcal infectious group, the other infectious group and the non-infectious group. CONCLUSIONS: Streptococcal infection is the most frequent trigger for childhood HSP and does not aggravate renal pathological damage; the possible elimination of streptococcal infection helps relieve the relapse/recurrence of HSP.
BACKGROUND: The present study focuses on the associations of streptococcal infection with the clinical phenotypes, relapse/recurrence and renal involvement in Henoch-Schönlein purpura (HSP) children. METHODS: Two thousand seventy-four Chinese children with HSP were recruited from January 2015 to December 2019. Patients' histories associated with HSP onset were obtained by interviews and questionnaires. Laboratory data of urine tests, blood sample and infectious agents were collected. Renal biopsy was performed by the percutaneous technique. RESULTS: (1) Streptococcal infection was identified in 393 (18.9%) HSP patients, and served as the most frequent infectious trigger. (2) Among the 393 cases with streptococcal infection, 43.0% of them had arthritis/arthralgia, 32.1% had abdominal pain and 29.3% had renal involvement. (3) 26.1% of HSP patients relapsed or recurred more than 1 time within a 5-year observational period, and the relapse/recurrence rate in streptococcal infectious group was subjected to a 0.4-fold decrease as compared with the non-infectious group. (4) No significant differences in renal pathological damage were identified among the streptococcal infectious group, the other infectious group and the non-infectious group. CONCLUSIONS:Streptococcal infection is the most frequent trigger for childhood HSP and does not aggravate renal pathological damage; the possible elimination of streptococcal infection helps relieve the relapse/recurrence of HSP.
Authors: J C Jennette; R J Falk; P A Bacon; N Basu; M C Cid; F Ferrario; L F Flores-Suarez; W L Gross; L Guillevin; E C Hagen; G S Hoffman; D R Jayne; C G M Kallenberg; P Lamprecht; C A Langford; R A Luqmani; A D Mahr; E L Matteson; P A Merkel; S Ozen; C D Pusey; N Rasmussen; A J Rees; D G I Scott; U Specks; J H Stone; K Takahashi; R A Watts Journal: Arthritis Rheum Date: 2013-01
Authors: Raquel López-Mejías; Fernanda Genre; Belén Sevilla Pérez; Santos Castañeda; Norberto Ortego-Centeno; Javier Llorca; Begoña Ubilla; Sara Remuzgo-Martínez; Verónica Mijares; Trinitario Pina; Vanesa Calvo-Río; Ana Márquez; José A Miranda-Filloy; Antonio Navas Parejo; Marta Conde-Jaldón; Lourdes Ortiz-Fernández; Diego Argila; Maximiliano Aragües; Esteban Rubio; Manuel León Luque; Juan María Blanco-Madrigal; Eva Galíndez-Aguirregoikoa; Francisca González Escribano; J Gonzalo Ocejo-Vinyals; Javier Martín; Ricardo Blanco; Miguel A González-Gay Journal: Arthritis Res Ther Date: 2015-04-14 Impact factor: 5.156