Nicolò Mauro1, Mara Andrea Utzeri1, Paola Varvarà1, Gennara Cavallaro1,2. 1. Lab of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, via Archirafi 32, 90123 Palermo, Italy. 2. Advanced Technologies Network Center, University of Palermo, Viale delle Scienze, Ed. 18, 90128 Palermo, Italy.
Abstract
Cancer theranostics is a new concept of medical approach that attempts to combine in a unique nanoplatform diagnosis, monitoring and therapy so as to provide eradication of a solid tumor in a non-invasive fashion. There are many available solutions to tackle cancer using theranostic agents such as photothermal therapy (PTT) and photodynamic therapy (PDT) under the guidance of imaging techniques (e.g., magnetic resonance-MRI, photoacoustic-PA or computed tomography-CT imaging). Additionally, there are several potential theranostic nanoplatforms able to combine diagnosis and therapy at once, such as gold nanoparticles (GNPs), graphene oxide (GO), superparamagnetic iron oxide nanoparticles (SPIONs) and carbon nanodots (CDs). Currently, surface functionalization of these nanoplatforms is an extremely useful protocol for effectively tuning their structures, interface features and physicochemical properties. This approach is much more reliable and amenable to fine adjustment, reaching both physicochemical and regulatory requirements as a function of the specific field of application. Here, we summarize and compare the most promising metal- and carbon-based theranostic tools reported as potential candidates in precision cancer theranostics. We focused our review on the latest developments in surface functionalization strategies for these nanosystems, or hybrid nanocomposites consisting of their combination, and discuss their main characteristics and potential applications in precision cancer medicine.
pan class="Disease">Cancer theranostics is a new concept of medical approach that attempts to combine in a unique nanon>n class="Chemical">platform diagnosis, monitoring and therapy so as to provide eradication of a solid tumor in a non-invasive fashion. There are many available solutions to tackle cancer using theranostic agents such as photothermal therapy (PTT) and photodynamic therapy (PDT) under the guidance of imaging techniques (e.g., magnetic resonance-MRI, photoacoustic-PA or computed tomography-CT imaging). Additionally, there are several potential theranostic nanoplatforms able to combine diagnosis and therapy at once, such as gold nanoparticles (GNPs), graphene oxide (GO), superparamagnetic iron oxide nanoparticles (SPIONs) and carbon nanodots (CDs). Currently, surface functionalization of these nanoplatforms is an extremely useful protocol for effectively tuning their structures, interface features and physicochemical properties. This approach is much more reliable and amenable to fine adjustment, reaching both physicochemical and regulatory requirements as a function of the specific field of application. Here, we summarize and compare the most promising metal- and carbon-based theranostic tools reported as potential candidates in precision cancer theranostics. We focused our review on the latest developments in surface functionalization strategies for these nanosystems, or hybrid nanocomposites consisting of their combination, and discuss their main characteristics and potential applications in precision cancer medicine.
Authors: Salman A A Mohammed; Khawla S Khashan; Majid S Jabir; Farah A Abdulameer; Ghassan M Sulaiman; Mohsen S Al-Omar; Hamdoon A Mohammed; Aseel A Hadi; Riaz A Khan Journal: Biomed Res Int Date: 2022-03-08 Impact factor: 3.411
Authors: Rossella Santonocito; Manuelamaria Intravaia; Ivana Maria Caruso; Andrea Pappalardo; Giuseppe Trusso Sfrazzetto; Nunzio Tuccitto Journal: Nanoscale Adv Date: 2022-03-21
Authors: Yang Hao; Chih Kit Chung; Zhenfeng Yu; Ruben V Huis In 't Veld; Ferry A Ossendorp; Peter Ten Dijke; Luis J Cruz Journal: Pharmaceutics Date: 2022-01-04 Impact factor: 6.321