Ève Boissonnault1,2,3, Johanne Higgins4,5,6, Geneviève LaGarde4,5, Dorothy Barthélemy4,5,6, Céline Lamarre7,4,5, Jehane H Dagher7,4,5. 1. Physical Medicine and Rehabilitation Service, Université de Montréal, Montreal, QC, Canada. eve.boissonnault@umontreal.ca. 2. Institut universitaire sur la réadaptation en déficience physique de Montréal (IURDPM), 6300, avenue de Darlington (Pavillon Gingras), Montréal, QC, H3S 2J4, Canada. eve.boissonnault@umontreal.ca. 3. Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), Montreal, QC, Canada. eve.boissonnault@umontreal.ca. 4. Institut universitaire sur la réadaptation en déficience physique de Montréal (IURDPM), 6300, avenue de Darlington (Pavillon Gingras), Montréal, QC, H3S 2J4, Canada. 5. Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), Montreal, QC, Canada. 6. School of Rehabilitation, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada. 7. Physical Medicine and Rehabilitation Service, Université de Montréal, Montreal, QC, Canada.
Abstract
BACKGROUND: After a traumatic brain injury, disturbances in the attentional processes have a direct negative effect on functional recovery and on return to complex activities. To date, there is no good attention remediation treatment available. The primary objective of this review and pilot study is to provide an overview of the research evidence and to evaluate the feasibility of implementing a tDCS protocol to improve attention disorders in patients with mild complicated to severe subacute TBI, hospitalized in an inpatient rehabilitation facility. Our secondary objective is to extract preliminary data and observational information on participants' response to treatment. METHODS: Participants were recruited from a consecutive series of patients admitted to the TBI unit of a subspecialized regional rehabilitation center. They received a 20-min tDCS stimulation 3 times a week for 3 weeks. A neuropsychological evaluation was performed before and after the intervention. We collected participants' sociodemographic and clinical characteristics as well as information about satisfaction, tolerability, and adverse effects. RESULTS: One hundred sixty-four patients were admitted between September 2018 and January 2020. One hundred fifty-eight were excluded, and 6 patients with presumed attentional deficits were enrolled. None completed the protocol as intended. No major side effects occurred. CONCLUSION: Non-invasive brain neurostimulation is promising to enhance attention deficits in patients with TBI. Implementation of a tDCS protocol to fulfill this purpose in an intensive inpatient rehabilitation center has its limitations. We made recommendations to facilitate the implementation of similar projects in the future. TRIAL REGISTRATION: ISRCTN, ISRCTN55243064 . Registered 14 October 2020-retrospectively registered.
BACKGROUND: After a traumatic brain injury, disturbances in the attentional processes have a direct negative effect on functional recovery and on return to complex activities. To date, there is no good attention remediation treatment available. The primary objective of this review and pilot study is to provide an overview of the research evidence and to evaluate the feasibility of implementing a tDCS protocol to improve attention disorders in patients with mild complicated to severe subacute TBI, hospitalized in an inpatient rehabilitation facility. Our secondary objective is to extract preliminary data and observational information on participants' response to treatment. METHODS:Participants were recruited from a consecutive series of patients admitted to the TBI unit of a subspecialized regional rehabilitation center. They received a 20-min tDCS stimulation 3 times a week for 3 weeks. A neuropsychological evaluation was performed before and after the intervention. We collected participants' sociodemographic and clinical characteristics as well as information about satisfaction, tolerability, and adverse effects. RESULTS: One hundred sixty-four patients were admitted between September 2018 and January 2020. One hundred fifty-eight were excluded, and 6 patients with presumed attentional deficits were enrolled. None completed the protocol as intended. No major side effects occurred. CONCLUSION: Non-invasive brain neurostimulation is promising to enhance attention deficits in patients with TBI. Implementation of a tDCS protocol to fulfill this purpose in an intensive inpatient rehabilitation center has its limitations. We made recommendations to facilitate the implementation of similar projects in the future. TRIAL REGISTRATION: ISRCTN, ISRCTN55243064 . Registered 14 October 2020-retrospectively registered.
Entities:
Keywords:
Attention; Brain injuries, Traumatic; Rehabilitation; Transcranial direct current stimulation; Transcranial magnetic stimulation
Authors: Asli Demirtas-Tatlidede; Andrew M Vahabzadeh-Hagh; Montserrat Bernabeu; Jose M Tormos; Alvaro Pascual-Leone Journal: J Head Trauma Rehabil Date: 2012 Jul-Aug Impact factor: 2.710
Authors: Ana Luiza Zaninotto; Mirret M El-Hagrassy; Jordan R Green; Maíra Babo; Vanessa Maria Paglioni; Glaucia Guerra Benute; Wellingson Silva Paiva Journal: Dement Neuropsychol Date: 2019 Apr-Jun