OBJECTIVE: To determine whether a single session of anodal transcranial direct current stimulation to the left dorsolateral prefrontal cortex improves attention in patients with traumatic brain injury. DESIGN: Double-blinded, cross-over design. PATIENTS: Nine patients with attention deficit after traumatic brain injury. METHODS: Patients underwent a computerized contrast reaction time task before and after the administration of real transcranial direct current stimulation (2 mA for 20 min) or sham transcranial direct current stimulation (2 mA for 1 min) to the left dorsolateral prefrontal cortex in a double-blind, crossover manner. RESULTS: Immediately post-stimulation, the transcranial direct current stimulation group showed a tendency of shortened reaction time relative to baseline (87.3 ± 7.8%), whereas the sham stimulation group (122.4 ± 715.5%) did not (p = 0.056). However, this difference was not significant 3 or 24 h after stimulation (p > 0.05). The numbers of correct responses were not changed at any time after stimulation. CONCLUSION:Anodal transcranial direct current stimulation applied to the left dorsolateral prefrontal cortex improves attention compared with sham stimulation in patients with traumatic brain injury, which suggests a potential role for this intervention in improving attention during cognitive training after traumatic brain injury. A further prospective randomized trial is required to confirm the benefits conferred by transcranial direct current stimulation in this patient population.
RCT Entities:
OBJECTIVE: To determine whether a single session of anodal transcranial direct current stimulation to the left dorsolateral prefrontal cortex improves attention in patients with traumatic brain injury. DESIGN: Double-blinded, cross-over design. PATIENTS: Nine patients with attention deficit after traumatic brain injury. METHODS:Patients underwent a computerized contrast reaction time task before and after the administration of real transcranial direct current stimulation (2 mA for 20 min) or sham transcranial direct current stimulation (2 mA for 1 min) to the left dorsolateral prefrontal cortex in a double-blind, crossover manner. RESULTS: Immediately post-stimulation, the transcranial direct current stimulation group showed a tendency of shortened reaction time relative to baseline (87.3 ± 7.8%), whereas the sham stimulation group (122.4 ± 715.5%) did not (p = 0.056). However, this difference was not significant 3 or 24 h after stimulation (p > 0.05). The numbers of correct responses were not changed at any time after stimulation. CONCLUSION: Anodal transcranial direct current stimulation applied to the left dorsolateral prefrontal cortex improves attention compared with sham stimulation in patients with traumatic brain injury, which suggests a potential role for this intervention in improving attention during cognitive training after traumatic brain injury. A further prospective randomized trial is required to confirm the benefits conferred by transcranial direct current stimulation in this patient population.
Authors: Daniel Neren; Matthew D Johnson; Wynn Legon; Salam P Bachour; Geoffrey Ling; Afshin A Divani Journal: Neurocrit Care Date: 2016-04 Impact factor: 3.210
Authors: Pariya L Fazeli; Adam J Woods; Caitlin N Pope; David E Vance; Karlene K Ball Journal: Appl Neuropsychol Adult Date: 2017-10-11 Impact factor: 2.248
Authors: Evan S Lutkenhoff; David L McArthur; Xue Hua; Paul M Thompson; Paul M Vespa; Martin M Monti Journal: Neuroimage Clin Date: 2013-10-05 Impact factor: 4.881