Farnaz Rasi-Bonab1, Abolfazl Jafari-Sales2, Mohammad Amin Shaverdi3,4, Tahereh Navidifar5, Morteza Saki6,7, Atosa Ghorbani6, Abimbola Olumide Adekanmbi8, Behboud Jafari9, Sara Naebi9. 1. Department of Microbiology, Marand Branch, Islamic Azad University, Marand, Iran. 2. Department of Microbiology, School of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran. a.jafari_1392@yahoo.com. 3. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran. aminshaverdi83@gmail.com. 4. Khuzestan Blood Transfusion Center, Abadan, Iran. aminshaverdi83@gmail.com. 5. Shoushtar Faculty of Medical Sciences, Shoushtar, Iran. 6. Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 7. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 8. Environmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Nigeria. 9. Department of Microbiology, Ahar Branch, Islamic Azad University, Ahar, Iran.
Abstract
OBJECTIVE: Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran. RESULTS: The culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%).
OBJECTIVE:Helicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran. RESULTS: The culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%).
Authors: Bram Flahou; Mirko Rossi; Jaco Bakker; Jan Am Langermans; Edwin Heuvelman; Jay V Solnick; Miriam E Martin; Jani O'Rourke; Le Duc Ngoan; Nguyen Xuan Hoa; Masahiko Nakamura; Anders Øverby; Hidenori Matsui; Hiroyoshi Ota; Takehisa Matsumoto; Dennis L Foss; Laurice A Kopta; Oladipo Omotosho; Maria Pia Franciosini; Patrizia Casagrande Proietti; Aizhen Guo; Han Liu; Gabriela Borilova; Ana Paula Bracarense; Sara K Lindén; Sofie De Bruyckere; Guangzhi Zhang; Chloë De Witte; Annemieke Smet; Frank Pasmans; Richard Ducatelle; Jukka Corander; Freddy Haesebrouck Journal: ISME J Date: 2017-09-08 Impact factor: 10.302
Authors: Antonietta Gerarda Gravina; Rocco Maurizio Zagari; Cristiana De Musis; Lorenzo Romano; Carmelina Loguercio; Marco Romano Journal: World J Gastroenterol Date: 2018-08-07 Impact factor: 5.742