| Literature DB >> 28885626 |
Bram Flahou1, Mirko Rossi2, Jaco Bakker3, Jan Am Langermans3, Edwin Heuvelman3, Jay V Solnick4, Miriam E Martin5, Jani O'Rourke6, Le Duc Ngoan7, Nguyen Xuan Hoa7, Masahiko Nakamura8, Anders Øverby8, Hidenori Matsui9, Hiroyoshi Ota10, Takehisa Matsumoto11, Dennis L Foss12, Laurice A Kopta12, Oladipo Omotosho13, Maria Pia Franciosini14, Patrizia Casagrande Proietti14, Aizhen Guo15, Han Liu15, Gabriela Borilova16, Ana Paula Bracarense17, Sara K Lindén18, Sofie De Bruyckere1, Guangzhi Zhang1, Chloë De Witte1, Annemieke Smet19, Frank Pasmans1, Richard Ducatelle1, Jukka Corander20,21, Freddy Haesebrouck1.
Abstract
Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys. The origin of modern human-, pig- or non-human primate-associated H. suis strains in these respective host populations was hitherto unknown. Here we show that H. suis in pigs possibly originates from non-human primates. Our data suggest that a host jump from macaques to pigs happened between 100 000 and 15 000 years ago and that pig domestication has had a significant impact on the spread of H. suis in the pig population, from where this pathogen occasionally infects humans. Thus, in contrast to our expectations, H. suis appears to have evolved in its main host in a completely different way than its close relative Helicobacter pylori in humans.Entities:
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Year: 2017 PMID： 28885626 PMCID： PMC5739005 DOI： 10.1038/ismej.2017.145
Source DB: PubMed Journal: ISME J ISSN： 1751-7362 Impact factor: 10.302