Manoja Kumar Das1, Narendra Kumar Arora2, John Mathai3, Cenita J Sam4, Rajamani G5, Krishnaswamy R6, Jothilakshmi K7, Pavai Arunachalam4, Bini Gupta2. 1. The INCLEN Trust International, F1/5, Okhla Industrial Area, Phase 1, New Delhi, 110020, India. manoj@inclentrust.org. 2. The INCLEN Trust International, F1/5, Okhla Industrial Area, Phase 1, New Delhi, 110020, India. 3. Department of Paediatrics, Masonic Medical Centre for Children, Racecourse, Coimbatore, Tamil Nadu, India. 4. Department of Paediatric Surgery, PSG Institute of Medical Sciences, Peelamedu, Coimbatore, Tamil Nadu, India. 5. Department of Paediatric Surgery, Coimbatore Medical College, Trichy Road, Coimbatore, Tamil Nadu, India. 6. Department of Pediatrics, Masonic Children's Hospital, Coimbatore, Tamil Nadu, India. 7. Department of Paediatrics, PSG Institute of Medical Sciences, Peelamedu, Tamil Nadu, Coimbatore, India.
Abstract
OBJECTIVE: To report background intussusception epidemiology in children under-two years in Coimbatore district of Tamil Nadu state, India, prior to rotavirus vaccine (RVV) introduction. METHODS: Prospective sentinel surveillance was done at four hospitals in Coimbatore during April 2016 to September 2017. The children aged >1 mo and < 24 mo with diagnosed intussusception were recruited and data on clinical, treatment, diet, immunization, and sociodemography were collected. RESULTS: Sixty-eight children with intussusception were recruited. Among them 76.5% were infants with male predominance (57.4%) and 48.5% were 4-8 mo old. Vomiting (83.8%), pain in abdomen (including excessive crying) (72.1%), and bloody stools (45.6%) were the main symptoms. Reduction was tried in 92.6% cases with success in 83.8%. Surgery was needed by 16.2% children. No child died. Any RVV dose was received by 24.1% children and 2 children received RVV in 8-21 d and none within 1-7 d window. The incidence of intussusception requiring hospitalization was estimated to be 36.4 and 11.7 cases/100,000 children/y for the first and second years, respectively. CONCLUSION: Intussusception occurred in infants even without RVV exposure. Continued surveillance is needed to document the changes in intussusception epidemiology after RVV introduction.
OBJECTIVE: To report background intussusception epidemiology in children under-two years in Coimbatore district of Tamil Nadu state, India, prior to rotavirus vaccine (RVV) introduction. METHODS: Prospective sentinel surveillance was done at four hospitals in Coimbatore during April 2016 to September 2017. The children aged >1 mo and < 24 mo with diagnosed intussusception were recruited and data on clinical, treatment, diet, immunization, and sociodemography were collected. RESULTS: Sixty-eight children with intussusception were recruited. Among them 76.5% were infants with male predominance (57.4%) and 48.5% were 4-8 mo old. Vomiting (83.8%), pain in abdomen (including excessive crying) (72.1%), and bloody stools (45.6%) were the main symptoms. Reduction was tried in 92.6% cases with success in 83.8%. Surgery was needed by 16.2% children. No child died. Any RVV dose was received by 24.1% children and 2 children received RVV in 8-21 d and none within 1-7 d window. The incidence of intussusception requiring hospitalization was estimated to be 36.4 and 11.7 cases/100,000 children/y for the first and second years, respectively. CONCLUSION: Intussusception occurred in infants even without RVV exposure. Continued surveillance is needed to document the changes in intussusception epidemiology after RVV introduction.