BACKGROUND: Intussusception is the most common cause of intestinal obstruction in young children and has been reported as a complication of a recently withdrawn tetravalent reassortant rotavirus vaccine. METHODS: We studied the history, clinical presentation, management and outcome of intussusception presenting to a tertiary care hospital in southern India over a 10-year period, in order to assess potential association with diarrheal disease and immunization. RESULTS: Data from 137 index cases and 280 control subjects indicated that the risk of diarrheal disease or oral polio vaccine administration in the month prior to presentation was similar in the index cases and controls. Mean time to presentation to hospital after developing symptoms was 1.8 days, and 77.3% of patients required surgery, with 47.4% undergoing intestinal resection. Mortality was 0.006%. CONCLUSIONS: No association could be demonstrated between gastroenteritis or oral poliovirus vaccine immunization and intussusception in southern Indian children. These children presented later and required operative intervention more frequently than has been reported in other studies, but had a good outcome with low mortality.
BACKGROUND: Intussusception is the most common cause of intestinal obstruction in young children and has been reported as a complication of a recently withdrawn tetravalent reassortant rotavirus vaccine. METHODS: We studied the history, clinical presentation, management and outcome of intussusception presenting to a tertiary care hospital in southern India over a 10-year period, in order to assess potential association with diarrheal disease and immunization. RESULTS: Data from 137 index cases and 280 control subjects indicated that the risk of diarrheal disease or oral polio vaccine administration in the month prior to presentation was similar in the index cases and controls. Mean time to presentation to hospital after developing symptoms was 1.8 days, and 77.3% of patients required surgery, with 47.4% undergoing intestinal resection. Mortality was 0.006%. CONCLUSIONS: No association could be demonstrated between gastroenteritis or oral poliovirus vaccine immunization and intussusception in southern Indian children. These children presented later and required operative intervention more frequently than has been reported in other studies, but had a good outcome with low mortality.
Authors: Manoja Kumar Das; Narendra Kumar Arora; Bini Gupta; Apoorva Sharan; K Kameswari; P Padmalatha; G Rajendra Prasad; Jimmy Shad; J Shyamala; S Harish Kumar; Yoga Nagender; K Sharmila; Rashmi Shad; Saurabh Garge; Lalit Bharadia; Atul Gupta; Jayanta K Goswami; Kaushik Lahiri; Lalit Sankhe; Sushant Mane; Yogini Prasad Patwari; M K Ajayakumar; A Santhosh Kumar; Rachita Sarangi; Bikasha Bihary Tripathy; S S G Mohapatra; Subrat Kumar Sahoo; Vijayendra Kumar; Rakesh Kumar; Suman Sarkar; Ruchirendu Sarkar; Nihar Ranjan Sarkar; Ashish Wakhlu; Simmi K Ratan; Anand P Dubey; Neelam Mohan; Meera Luthra; Bhadresh R Vyas; Harsh Trivedi; John Mathai; Cenita J Sam; K Jothilakshmi; Pavai Arunachalam; Javeed Iqbal Bhat; Gowhar Mufti; Bashir Ahmad Charoo; Pradeep K Jena; Sanjib K Debbarma; Sunil K Ghosh; Mahesh K Aggarwal; Pradeep Haldar; Patrick L F Zuber; Christine Maure; Jan Bonhoeffer; Arindam Ray Journal: Vaccine Date: 2020-06-15 Impact factor: 3.641