Ali Dulfikar1, Eng-Siew Koh2,3, Zarnie Lwin4,5, Elizabeth Hovey6,3, Haryana Dhillon7, Jesica Arundell2, Elizabeth Pinkham1,8, Mark B Pinkham1,9, Justin Holland1, Gabriel Trajano1, Fiona Naumann1. 1. School of Exercise and Nutrition Sciences, Queensland University of Technology, Kelvin Grove, Australia. 2. Radiation oncology, Liverpool Hospital, Liverpool, Australia. 3. University of New South Wales, Randwick, Australia. 4. Department of Medical Oncology, Royal Brisbane and Womens Hospital, Herston, Australia. 5. School of Medicine, University of Queensland, St Lucia, Australia. 6. Department of Medical Oncology, Nelune Comprehensive Cancer Centre, Prince of wales Hospital, Randwick, Australia. 7. Centre for Medical Psychology & Evidence-Based Decision-Making, School of Psychology Faculty of Science, The University of Sydney, Camperdown, Australia. 8. Physiotherapy, Clinical Support Services, Princess Alexandra Hospital, Woollongabba, Australia. 9. Radiation Oncology, Cancer Services, Princess Alexandra Hospital, Woolloongabba, Australia.
Abstract
BACKGROUND: Few studies have assessed physical functioning in glioma patients with grade II, III, and IV glioma prior to undergoing adjuvant radiation with or without chemotherapy. The aim of this study was to describe the baseline physical functioning capacity of patients with glioma prior to adjuvant therapy compared to validated cutoffs required to maintain independence. METHODS: This study is a cross-sectional study that recruited patients with grade II, III, and IV glioma (n = 33) undergoing adjuvant radiation with or without chemotherapy. The six-minute walk, thirty-second sit-to-stand, and timed "Up & Go" assessments were used to describe baseline physical functioning. Perceived quality of life from the European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ-C30) version 3.0 was used to quantify the quality of life. RESULTS: Mean distance walked in the six-minute walk test was 416.2 m (SD 137.6 m) with a mean of 12.2 stands (SD 3.4 stands) achieved during the thirty-second sit-to-stand. Median time to complete the timed "Up & Go" assessment was 7 s (interquartile range: 3 s). One-sample t tests suggest walking distance and chair stands were significantly lower than cutoff criterions to maintain independent living, t(32) = -5.96, P < .001, bias-corrected accelerated 95% CI [370.7-460.4], and t(32) = -4.60, P < .01, bias-corrected accelerated 95% CI [11.0-13.4], respectively. Wilcoxon signed-rank test identified significantly shorter median time taken to complete the timed "Up & Go" test compared to the cutoff criterion (z = -4.43, n = 33, P < .01). CONCLUSION: This study suggests glioma patient's aerobic endurance and lower limb strength are below criterion cutoffs recommended to maintain independent living. Timed "Up & Go" scores did not exceed the criterion cutoff, indicating respectable levels of mobility.
BACKGROUND: Few studies have assessed physical functioning in glioma patients with grade II, III, and IV glioma prior to undergoing adjuvant radiation with or without chemotherapy. The aim of this study was to describe the baseline physical functioning capacity of patients with glioma prior to adjuvant therapy compared to validated cutoffs required to maintain independence. METHODS: This study is a cross-sectional study that recruited patients with grade II, III, and IV glioma (n = 33) undergoing adjuvant radiation with or without chemotherapy. The six-minute walk, thirty-second sit-to-stand, and timed "Up & Go" assessments were used to describe baseline physical functioning. Perceived quality of life from the European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ-C30) version 3.0 was used to quantify the quality of life. RESULTS: Mean distance walked in the six-minute walk test was 416.2 m (SD 137.6 m) with a mean of 12.2 stands (SD 3.4 stands) achieved during the thirty-second sit-to-stand. Median time to complete the timed "Up & Go" assessment was 7 s (interquartile range: 3 s). One-sample t tests suggest walking distance and chair stands were significantly lower than cutoff criterions to maintain independent living, t(32) = -5.96, P < .001, bias-corrected accelerated 95% CI [370.7-460.4], and t(32) = -4.60, P < .01, bias-corrected accelerated 95% CI [11.0-13.4], respectively. Wilcoxon signed-rank test identified significantly shorter median time taken to complete the timed "Up & Go" test compared to the cutoff criterion (z = -4.43, n = 33, P < .01). CONCLUSION: This study suggests glioma patient's aerobic endurance and lower limb strength are below criterion cutoffs recommended to maintain independent living. Timed "Up & Go" scores did not exceed the criterion cutoff, indicating respectable levels of mobility.
Authors: Lee W Jones; Yuanyuan Liang; Edith N Pituskin; Claudio L Battaglini; Jessica M Scott; Whitney E Hornsby; Mark Haykowsky Journal: Oncologist Date: 2011-01-06
Authors: Lee W Jones; Allan H Friedman; Miranda J West; Stephanie K Mabe; Jennifer Fraser; William E Kraus; Henry S Friedman; Maura I Tresch; Nancy Major; David A Reardon Journal: Cancer Date: 2010-02-01 Impact factor: 6.860
Authors: James L Rogers; Julianie De La Cruz Minyety; Elizabeth Vera; Alvina A Acquaye; Samuel S Payén; Jeffrey S Weinberg; Terri S Armstrong; Shiao-Pei S Weathers Journal: Neurooncol Pract Date: 2022-02-17