Pablo Hernández-Alonso1,2,3,4, Silvia Canudas1,2,4, Hatim Boughanem3, Estefanía Toledo4,5,6, Jose V Sorlí4,7, Ramón Estruch4,8,9, Olga Castañer4,10, José Lapetra4,11, Angel M Alonso-Gómez4,12, Mario Gutiérrez-Bedmar13, Miquel Fiol4,14, Lluis Serra-Majem4,15, Xavier Pintó4,16, Emilio Ros4,17, Cesar I Fernandez-Lazaro5, Judith B Ramirez-Sabio18, Montse Fitó4,10, Joseba Portu-Zapirain19,20, Manuel Macias-González21,22, Nancy Babio23,24,25, Jordi Salas-Salvadó1,2,4. 1. Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, C/Sant Llorenç 21, 43201, Reus, Spain. 2. Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari San Joan de Reus, 43204, Reus, Spain. 3. Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Institute of Biomedical Research in Malaga (IBIMA), University of Malaga, 29016, Málaga, Spain. 4. Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain. 5. Department of Preventive Medicine and Public Health, Universidad de Navarra, 31008, Pamplona, Spain. 6. IdiSNA, Navarra Institute for Health Research, 31008, Pamplona, Spain. 7. Department of Preventive Medicine, Universidad de Valencia, 46010, Valencia, Spain. 8. Cardiovascular Risk, Nutrition and Aging Research Unit, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08003, Barcelona, Spain. 9. Internal Medicine Service, Hospital Clínic, 08036, Barcelona, Spain. 10. Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Medical Research Institute (IMIM), 08003, Barcelona, Spain. 11. Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, 41013, Sevilla, Spain. 12. Bioaraba Health Research Institute, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, 01002, Vitoria-Gasteiz, Spain. 13. Department of Preventive Medicine and Public Health, School of Medicine, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, 29010, Málaga, Spain. 14. Health Research Institute of the Balearic Islands (IdISBa), Hospital Son Espases, 07120, Palma de Mallorca, Spain. 15. Institute for Biomedical and Health Research, Universidad de Las Palmas de Gran Canaria, 35016, Las Palmas, Spain. 16. Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-Idibell, 08907, L'Hospitalet de Llobregat, Spain. 17. Lipid Clinic, Department of Endocrinology and Nutrition Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. 18. Servicio de Oncología, Hospital de Sagunto, 46520, Valencia, Spain. 19. Bioaraba, Infectious Diseases Research Group, Vitoria-Gasteiz, Spain. 20. Internal Medicine Department, Osakidetza Basque Health Service, Araba University Hospital, Vitoria-Gasteiz, Spain. 21. Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Institute of Biomedical Research in Malaga (IBIMA), University of Malaga, 29016, Málaga, Spain. mmacias.manuel@gmail.com. 22. Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain. mmacias.manuel@gmail.com. 23. Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, C/Sant Llorenç 21, 43201, Reus, Spain. nancy.babio@urv.cat. 24. Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari San Joan de Reus, 43204, Reus, Spain. nancy.babio@urv.cat. 25. Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain. nancy.babio@urv.cat.
Abstract
PURPOSE: We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk. METHODS: We analyzed data from 7216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake. RESULTS: During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30-1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22-0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28-0.96) and 0.41 (0.12-0.85), respectively]. CONCLUSION: A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk.
PURPOSE: We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk. METHODS: We analyzed data from 7216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake. RESULTS: During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30-1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22-0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28-0.96) and 0.41 (0.12-0.85), respectively]. CONCLUSION: A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk.
Entities:
Keywords:
Cancer; Colorectal cancer; PREDIMED; Risk; Vitamin D
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