Literature DB >> 34046794

Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin.

E A Akoulina1, I V Demianova2, I I Zharkova2, V V Voinova2, V A Zhuikov3, D D Khaydapova4, D V Chesnokova2, K A Menshikh2, A A Dudun3, T K Makhina3, G A Bonartseva3, A V Volkov4, T F Asfarov4, S Y Ivanov4,5, K V Shaitan2, A P Bonartsev2,3.   

Abstract

We studied the effect of porous composite scaffolds based on poly(3-hydroxybutyrate) (PHB) loaded with simvastatin on the growth and differentiation of mesenchymal stem cells. The scaffolds have a suitable microstructure (porosity and pore size) and physicochemical properties to support the growth of mesenchymal stem cells. Scaffold loading with simvastatin suppressed cell growth and increased alkaline phosphatase activity, which can attest to their osteoinductive properties.

Entities:  

Keywords:  hydroxyapatite; osteoinductive; poly(3-hydroxybutyrate); scaffolds; simvastatin

Mesh：

Substances：

Year:  2021        PMID： 34046794     DOI： 10.1007/s10517-021-05190-8

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

Review 1.  Kinetic modeling on drug release from controlled drug delivery systems.

Authors:  Suvakanta Dash; Padala Narasimha Murthy; Lilakanta Nath; Prasanta Chowdhury
Journal:  Acta Pol Pharm       Date:  2010 May-Jun       Impact factor: 0.330

Review 2.  Porosity of 3D biomaterial scaffolds and osteogenesis.

Authors:  Vassilis Karageorgiou; David Kaplan
Journal:  Biomaterials       Date:  2005-09       Impact factor: 12.479

Review 3.  Hydroxyapatite-polymer biocomposites for bone regeneration: A review of current trends.

Authors:  Niranjan Ramesh; Stephen C Moratti; George J Dias
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2017-06-26       Impact factor: 3.368

4.  The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects.

Authors:  Risa Ikeda; Hiroyuki Fujioka; Issei Nagura; Takeshi Kokubu; Narikazu Toyokawa; Atsuyuki Inui; Takeshi Makino; Hiroaki Kaneko; Minoru Doita; Masahiro Kurosaka
Journal:  Int Orthop       Date:  2008-04-16       Impact factor: 3.075

5.  Poly(3-hydroxybutyrate)/hydroxyapatite/alginate scaffolds seeded with mesenchymal stem cells enhance the regeneration of critical-sized bone defect.

Authors:  Alexey V Volkov; Alexander A Muraev; Irina I Zharkova; Vera V Voinova; Elizaveta A Akoulina; Vsevolod A Zhuikov; Dolgor D Khaydapova; Dariana V Chesnokova; Ksenia A Menshikh; Andrej A Dudun; Tatiana K Makhina; Garina A Bonartseva; Teymur F Asfarov; Ivan A Stamboliev; Yulia V Gazhva; Valentina M Ryabova; Lubomir H Zlatev; Sergey Y Ivanov; Konstantin V Shaitan; Anton P Bonartsev
Journal:  Mater Sci Eng C Mater Biol Appl       Date:  2020-04-25       Impact factor: 7.328

6.  Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation.

Authors:  Mehdi Shakibaei; Parviz Shayan; Franziska Busch; Constance Aldinger; Constanze Buhrmann; Cora Lueders; Ali Mobasheri
Journal:  PLoS One       Date:  2012-04-23       Impact factor: 3.240

Review 7.  Effect of poly(3-hydroxyalkanoates) as natural polymers on mesenchymal stem cells.

Authors:  Vera Voinova; Garina Bonartseva; Anton Bonartsev
Journal:  World J Stem Cells       Date:  2019-10-26       Impact factor: 5.326

8.  Controlled release of simvastatin from biomimetic β-TCP drug delivery system.

Authors:  Joshua Chou; Tomoko Ito; David Bishop; Makoto Otsuka; Besim Ben-Nissan; Bruce Milthorpe
Journal:  PLoS One       Date:  2013-01-18       Impact factor: 3.240
  8 in total

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