Literature DB >> 34046791

The Effect of Transplantation of Olfactory Ensheathing Cells on the Size of Posttraumatic Spinal Cord Cysts.

A D Voronova1, O V Stepanova2,3, A V Chadin2, G A Fursa2,4, E K Karsuntseva2,4, M P Valikhov2,3, А S Semkina2,5, I V Reshetov6, V P Chekhonin2,5.   

Abstract

We studied the effect of transplantation of ensheathing cells obtained from the olfactory mucosa of rats and humans on the size of posttraumatic spinal cord cysts. MRI examination showed that transplantation of these cells into experimental posttraumatic cysts of the spinal cord led to a significant decrease in cyst volume and even their complete disappearance in two animals receiving transplantation of rat or human cells. These findings attested to regenerative processes developing as a result of ensheathing cell transplantation. Further studies in this field will be aimed at elucidation of the mechanisms underlying spinal cord regeneration in the area of posttraumatic cysts after transplantation of ensheathing cells.

Entities:  

Keywords:  cell therapy; human olfactory mucosa; olfactory ensheathing cells; posttraumatic cysts of the spinal cord

Mesh：

Year:  2021        PMID： 34046791     DOI： 10.1007/s10517-021-05183-7

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  19 in total

Review 1.  Designing cell- and gene-based regeneration strategies to repair the injured spinal cord.

Authors:  D D Pearse; M B Bunge
Journal:  J Neurotrauma       Date:  2006 Mar-Apr       Impact factor: 5.269

2.  Lamina propria and olfactory bulb ensheathing cells exhibit differential integration and migration and promote differential axon sprouting in the lesioned spinal cord.

Authors:  Miranda W Richter; Patrick A Fletcher; Jie Liu; Wolfram Tetzlaff; A Jane Roskams
Journal:  J Neurosci       Date:  2005-11-16       Impact factor: 6.167

Review 3.  Plasticity and regeneration in the injured spinal cord after cell transplantation therapy.

Authors:  Satoshi Nori; Masaya Nakamura; Hideyuki Okano
Journal:  Prog Brain Res       Date:  2017-01-17       Impact factor: 2.453

4.  Neuroprotective effects of human spinal cord-derived neural precursor cells after transplantation to the injured spinal cord.

Authors:  Mia Emgård; Jinghua Piao; Helena Aineskog; Jia Liu; Cinzia Calzarossa; Jenny Odeberg; Lena Holmberg; Eva-Britt Samuelsson; Bartosz Bezubik; Per Henrik Vincent; Scott P Falci; Åke Seiger; Elisabet Åkesson; Erik Sundström
Journal:  Exp Neurol       Date:  2014-01-08       Impact factor: 5.330

5.  Study of the efficiency of transplantation of human neural stem cells to rats with spinal trauma: the use of functional load tests and BBB test.

Authors:  S V Lebedev; A V Karasev; V P Chekhonin; E A Savchenko; I V Viktorov; Yu A Chelyshev; G F Shaimardanova
Journal:  Bull Exp Biol Med       Date:  2010-09       Impact factor: 0.804

6.  Limited functional recovery in rats with complete spinal cord injury after transplantation of whole-layer olfactory mucosa: laboratory investigation.

Authors:  Masanori Aoki; Haruhiko Kishima; Kazuhiro Yoshimura; Masahiro Ishihara; Masaki Ueno; Katsuhiko Hata; Toshihide Yamashita; Koichi Iwatsuki; Toshiki Yoshimine
Journal:  J Neurosurg Spine       Date:  2010-02

7.  Functional assessment of the acute local and distal transplantation of human neural stem cells after spinal cord injury.

Authors:  Ivan Cheng; Robert E Mayle; Christopher A Cox; Don Y Park; Robert L Smith; Ian Corcoran-Schwartz; Karthikeyan E Ponnusamy; Rayshad Oshtory; Matthew W Smuck; Raj Mitra; Alexander I Kharazi; Eugene J Carragee
Journal:  Spine J       Date:  2012-10-12       Impact factor: 4.166

8.  FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis.

Authors:  Alessandra Santos-Silva; Richard Fairless; Margaret C Frame; Paul Montague; George M Smith; Andrew Toft; John S Riddell; Susan C Barnett
Journal:  J Neurosci       Date:  2007-07-04       Impact factor: 6.167

9.  Post-traumatic syringomyelia.

Authors:  Amit Agrawal; M Shantharam Shetty; Lekha Pandit; Lathika Shetty; U Srikrishna
Journal:  Indian J Orthop       Date:  2007-10       Impact factor: 1.251

10.  Transplantation of Neural Precursor Cells Attenuates Chronic Immune Environment in Cervical Spinal Cord Injury.

Authors:  Lennart Riemann; Alexander Younsi; Moritz Scherer; Guoli Zheng; Thomas Skutella; Andreas W Unterberg; Klaus Zweckberger
Journal:  Front Neurol       Date:  2018-06-08       Impact factor: 4.003
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  2 in total

1.  Neurotrophin-3 Enhances the Effectiveness of Cell Therapy in Chronic Spinal Cord Injuries.

Authors:  O V Stepanova; A D Voronova; A V Chadin; G A Fursa; E K Karsuntseva; M P Valikhov; A S Semkina; I V Reshetov; V P Chekhonin
Journal:  Bull Exp Biol Med       Date:  2022-05-27       Impact factor: 0.804

2.  Obtaining a New Gene-Cell Construct Based on Transduced Olfactory Ensheathing Cells for the Treatment of Spinal Cord Injuries.

Authors:  A D Voronova; A O Sosnovtseva; O V Stepanova; A V Chadin; E K Karsuntseva; G A Fursa; I V Reshetov; V P Chekhonin
Journal:  Bull Exp Biol Med       Date:  2022-09-05       Impact factor: 0.737
  2 in total

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