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Literature DB >> 36058977

Obtaining a New Gene-Cell Construct Based on Transduced Olfactory Ensheathing Cells for the Treatment of Spinal Cord Injuries.

A D Voronova¹, A O Sosnovtseva², O V Stepanova^2,3, A V Chadin², E K Karsuntseva², G A Fursa^2,4, I V Reshetov⁵, V P Chekhonin².

Abstract

We developed a viral vector Ad5/35-CAG-mBDNF expressing the mature form of BDNF (mBDNF). On the basis of olfactory ensheathing cells transduced with this adenovector, a new gene-cell construct was obtained. In experiments in vitro, high viability of the transduced olfactory ensheathing cells and enhanced secretion of BDNF by these cells were observed. It is possible that a new gene-cell construct will significantly increase the regenerative effects of transplanted olfactory ensheathing cells.

Entities: Chemical

Keywords: brain-derived neurotrophic factor; gene-cell therapy; olfactory ensheathing cells; spinal cord injury

Mesh：

Substances：

Year: 2022 PMID： 36058977 DOI： 10.1007/s10517-022-05576-2

Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.737

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References

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Obtaining a New Gene-Cell Construct Based on Transduced Olfactory Ensheathing Cells for the Treatment of Spinal Cord Injuries.

1. Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood-brain barrier using focused ultrasound and microbubbles.

2. Gene therapy, early promises, subsequent problems, and recent breakthroughs.

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4. Evaluation of adenovirus vectors containing serotype 35 fibers for vaccination.

5. Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury.

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