Robbie S R Woods1, Deirdre Callanan2,3, Hadeel Jawad4, Peter Molony4, Reiltin Werner4, Cynthia Heffron4, Linda Feeley4,3, Patrick Sheahan2,5,3. 1. Department of Otolaryngology, South Infirmary Victoria University Hospital, Cork, T12 X23H, Ireland. robbiewoods@rcsi.com. 2. Department of Otolaryngology, South Infirmary Victoria University Hospital, Cork, T12 X23H, Ireland. 3. ENTO Research Unit, College of Medicine and Health, University College Cork, Cork, Ireland. 4. Department of Histopathology, Cork University Hospital, Cork, Ireland. 5. Department of Surgery, University College Cork, Cork, Ireland.
Abstract
PURPOSE: The precise etiopathogenesis of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC), and reasons for predilection for crypt epithelium, remain uncertain. The purpose of this study is to investigate the interaction between HPV and specific cytokeratins 7 (CK7) and 19 (CK19) in crypt epithelium. METHODS: This is a retrospective cohort study of patients presenting between 1999 and 2015 at a tertiary referral center. CK7 and CK19 positivity and H Scores were determined by immunohistochemistry. Disease-specific and overall survival rates were analyzed. RESULTS: There were 253 patients presenting with OPSCC (134), squamous cell carcinoma (SCC) of unknown primary site (22), and oral tongue SCC (97). Primary tumor CK7 and CK19 positivity and H Scores were significantly higher in HPV-positive OPSCC than HPV-negative OPSCC and oral tongue SCC. Higher CK19 Scores, but not CK7 Scores, were also seen in regional metastases from HPV-positive OPSCC than other sites. No impact on disease-specific or overall survival was identified on multivariate analysis. CONCLUSION: The increased expression of CK7 and CK19 in HPV-positive OPSCC compared to HPV-negative disease supports the theory for a role for these cytokeratins in the etiopathogenesis of HPV-related OPSCC.
PURPOSE: The precise etiopathogenesis of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC), and reasons for predilection for crypt epithelium, remain uncertain. The purpose of this study is to investigate the interaction between HPV and specific cytokeratins 7 (CK7) and 19 (CK19) in crypt epithelium. METHODS: This is a retrospective cohort study of patients presenting between 1999 and 2015 at a tertiary referral center. CK7 and CK19 positivity and H Scores were determined by immunohistochemistry. Disease-specific and overall survival rates were analyzed. RESULTS: There were 253 patients presenting with OPSCC (134), squamous cell carcinoma (SCC) of unknown primary site (22), and oral tongue SCC (97). Primary tumor CK7 and CK19 positivity and H Scores were significantly higher in HPV-positive OPSCC than HPV-negative OPSCC and oral tongue SCC. Higher CK19 Scores, but not CK7 Scores, were also seen in regional metastases from HPV-positive OPSCC than other sites. No impact on disease-specific or overall survival was identified on multivariate analysis. CONCLUSION: The increased expression of CK7 and CK19 in HPV-positive OPSCC compared to HPV-negative disease supports the theory for a role for these cytokeratins in the etiopathogenesis of HPV-related OPSCC.
Authors: Harriet C Hafkamp; Ernst J M Speel; Annick Haesevoets; Fredrik J Bot; Winand N M Dinjens; Frans C S Ramaekers; Anton H N Hopman; Johannes J Manni Journal: Int J Cancer Date: 2003-11-10 Impact factor: 7.396
Authors: Michael J Lace; James R Anson; Aloysius J Klingelhutz; John H Lee; Aaron D Bossler; Thomas H Haugen; Lubomir P Turek Journal: J Virol Date: 2009-09-09 Impact factor: 5.103