Literature DB >> 30327906

The 8th edition AJCC/UICC TNM staging for p16-positive oropharyngeal carcinoma: is there space for improvement?

Shachi Jenny Sharma1, Steffen Wagner2, Henrike Simone Frauke Reder2, Tobias Kroll3, Nora Wuerdemann3, Jens Peter Klussmann3, Claus Wittekindt2.   

Abstract

The 8th edition of the AJCC/UICC TNM-staging system for p16[HPV]-positive OPSCC manages to improve prediction of prognosis and will essentially influence choice of therapy in future. Nonetheless, adjustments of the current version are needed. The surrogate marker p16 alone is inadequate for HPV detection, the role of ECS in HPV-positive OPSCC is not fully understood, and the patient's characteristics as well as molecular signatures and genetics have not been taken into consideration yet.

Entities:  

Keywords:  AJCC; Human papillomavirus (HPV); Neoplasm staging; OPSCC; Oropharyngeal cancer; TNM classification; UICC

Mesh：

Substances：

Year:  2018        PMID： 30327906     DOI： 10.1007/s00405-018-5156-4

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  23 in total

1.  Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas.

Authors:  Shao Hui Huang; Wei Xu; John Waldron; Lillian Siu; Xiaowei Shen; Li Tong; Jolie Ringash; Andrew Bayley; John Kim; Andrew Hope; John Cho; Meredith Giuliani; Aaron Hansen; Jonathan Irish; Ralph Gilbert; Patrick Gullane; Bayardo Perez-Ordonez; Ilan Weinreb; Fei-Fei Liu; Brian O'Sullivan
Journal:  J Clin Oncol       Date:  2015-02-09       Impact factor: 44.544

2.  High metastatic node number, not extracapsular spread or N-classification is a node-related prognosticator in transorally-resected, neck-dissected p16-positive oropharynx cancer.

Authors:  Parul Sinha; Dorina Kallogjeri; Hiram Gay; Wade L Thorstad; James S Lewis; Rebecca Chernock; Brian Nussenbaum; Bruce H Haughey
Journal:  Oral Oncol       Date:  2015-03-12       Impact factor: 5.337

3.  Validation of the ICON-S staging for HPV-associated oropharyngeal carcinoma using a pre-defined treatment policy.

Authors:  Sandro V Porceddu; Rob Milne; Elizabeth Brown; Anne Bernard; Reza Rahbari; Bena Cartmill; Matthew Foote; Margaret McGrath; Jermaine Coward; Benedict Panizza
Journal:  Oral Oncol       Date:  2017-01-21       Impact factor: 5.337

4.  Extracapsular spread in head and neck carcinoma: impact of site and human papillomavirus status.

Authors:  Jessica H Maxwell; Robert L Ferris; William Gooding; Diana Cunningham; Vikas Mehta; Seungwon Kim; Eugene N Myers; Jonas Johnson; Simion Chiosea
Journal:  Cancer       Date:  2013-06-24       Impact factor: 6.860

Review 5.  Overview of the 8th Edition TNM Classification for Head and Neck Cancer.

Authors:  Shao Hui Huang; Brian O'Sullivan
Journal:  Curr Treat Options Oncol       Date:  2017-07

6.  Risk Factors for Overall Survival Outcome in Surgically Treated Human Papillomavirus-Negative and Positive Patients with Oropharyngeal Cancer.

Authors:  Nora Wuerdemann; Claus Wittekindt; Shachi Jenny Sharma; Elena-Sophie Prigge; Miriam Reuschenbach; Stefan Gattenlöhner; Jens Peter Klussmann; Steffen Wagner
Journal:  Oncol Res Treat       Date:  2017-05-17       Impact factor: 2.825

7.  Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus.

Authors:  Jens P Klussmann; Elif Gültekin; Soenke J Weissenborn; Ulrike Wieland; Volker Dries; Hans P Dienes; Hans E Eckel; Herbert J Pfister; Pawel G Fuchs
Journal:  Am J Pathol       Date:  2003-03       Impact factor: 4.307

8.  Observer variation in the histopathologic assessment of extranodal tumor spread in lymph node metastases in the neck.

Authors:  Michiel W M van den Brekel; Wouter L Lodder; Herbert V Stel; Elisabeth Bloemena; C René Leemans; Isaäc van der Waal
Journal:  Head Neck       Date:  2011-08-24       Impact factor: 3.147

9.  Nodal status is not a prognostic factor in patients with HPV-positive oral/oropharyngeal tumors.

Authors:  Jan Klozar; Eva Koslabova; Vit Kratochvil; Martina Salakova; Ruth Tachezy
Journal:  J Surg Oncol       Date:  2012-11-28       Impact factor: 3.454

10.  Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx.

Authors:  B H Haughey; P Sinha; D Kallogjeri; R L Goldberg; J S Lewis; J F Piccirillo; R S Jackson; E J Moore; M Brandwein-Gensler; S J Magnuson; W R Carroll; T M Jones; M D Wilkie; A Lau; N S Upile; Jon Sheard; J Lancaster; S Tandon; M Robinson; D Husband; I Ganly; J P Shah; D M Brizel; B O'Sullivan; J A Ridge; W M Lydiatt
Journal:  Oral Oncol       Date:  2016-09-23       Impact factor: 5.337
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  3 in total

1.  DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1.

Authors:  Chunlin Zhang; Jiaoping Mi; Yuan Deng; Zeyi Deng; Dan Long; Zhaohui Liu
Journal:  Onco Targets Ther       Date:  2020-05-15       Impact factor: 4.147

2.  Cytokeratin 7 and 19 expression in oropharyngeal and oral squamous cell carcinoma.

Authors:  Robbie S R Woods; Deirdre Callanan; Hadeel Jawad; Peter Molony; Reiltin Werner; Cynthia Heffron; Linda Feeley; Patrick Sheahan
Journal:  Eur Arch Otorhinolaryngol       Date:  2021-05-27       Impact factor: 2.503

3.  Evaluation of prognostic biomarkers in a population-validated Finnish HNSCC patient cohort.

Authors:  J Routila; I Leivo; H Minn; J Westermarck; Sami Ventelä
Journal:  Eur Arch Otorhinolaryngol       Date:  2021-02-13       Impact factor: 2.503
  3 in total

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