Roberta Fusco1, Vincenza Granata2, Mario Sansone3, Daniela Rega4, Paolo Delrio4, Fabiana Tatangelo5, Carmen Romano6, Antonio Avallone6, Davide Pupo7, Marzia Giordano7, Roberto Grassi7, Vincenzo Ravo8, Biagio Pecori8, Antonella Petrillo2. 1. Radiology Unit, Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Via Mariano Semmola, 80131, Naples, Italy. r.fusco@istitutotumori.na.it. 2. Radiology Unit, Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Via Mariano Semmola, 80131, Naples, Italy. 3. Department of Electrical Engineering and Information Technologies, University Federico II of Naples, Via Claudio, Naples, Italy. 4. Gastrointestinal Surgical Oncology Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Via Mariano Semmola, 80131, Naples, Italy. 5. Diagnostic Pathology Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Via Mariano Semmola, 80131, Naples, Italy. 6. Gastrointestinal Medical Oncology Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Via Mariano Semmola, 80131, Naples, Italy. 7. Division of Radiology, Università Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy. 8. Radiotherapy Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Via Mariano Semmola, 80131, Naples, Italy.
Abstract
PURPOSE: Standardized index of shape (SIS) tool validation to examine dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in preoperative chemo-radiation therapy (pCRT) assessment of locally advanced rectal cancer (LARC) in order to guide the surgeon versus more or less conservative treatment. MATERIALS AND METHODS: A total of 194 patients (January 2008-November 2020), with III-IV locally advanced rectal cancer and subjected to pCRT were included. Three expert radiologists performed DCE-MRI analysis using SIS tool. Degree of absolute agreement among measurements, degree of consistency among measurements, degree of reliability and level of variability were calculated. Patients with a pathological tumour regression grade (TRG) 1 or 2 were classified as major responders (complete responders have TRG 1). RESULTS: Good significant correlation was obtained between SIS measurements (range 0.97-0.99). The degree of absolute agreement ranges from 0.93 to 0.99, the degree of consistency from 0.81 to 0.9 and the reliability from 0.98 to 1.00 (p value < < 0.001). The variability coefficient ranges from 3.5% to 26%. SIS value obtained to discriminate responders by non-responders a sensitivity of 95.9%, a specificity of 84.7% and an accuracy of 91.8% while to detect complete responders, a sensitivity of 99.2%, a specificity of 63.9% and an accuracy of 86.1%. CONCLUSION: SIS tool is suitable to assess pCRT response both to identify major responders and complete responders in order to guide the surgeon versus more or less conservative treatment.
PURPOSE: Standardized index of shape (SIS) tool validation to examine dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in preoperative chemo-radiation therapy (pCRT) assessment of locally advanced rectal cancer (LARC) in order to guide the surgeon versus more or less conservative treatment. MATERIALS AND METHODS: A total of 194 patients (January 2008-November 2020), with III-IV locally advanced rectal cancer and subjected to pCRT were included. Three expert radiologists performed DCE-MRI analysis using SIS tool. Degree of absolute agreement among measurements, degree of consistency among measurements, degree of reliability and level of variability were calculated. Patients with a pathological tumour regression grade (TRG) 1 or 2 were classified as major responders (complete responders have TRG 1). RESULTS: Good significant correlation was obtained between SIS measurements (range 0.97-0.99). The degree of absolute agreement ranges from 0.93 to 0.99, the degree of consistency from 0.81 to 0.9 and the reliability from 0.98 to 1.00 (p value < < 0.001). The variability coefficient ranges from 3.5% to 26%. SIS value obtained to discriminate responders by non-responders a sensitivity of 95.9%, a specificity of 84.7% and an accuracy of 91.8% while to detect complete responders, a sensitivity of 99.2%, a specificity of 63.9% and an accuracy of 86.1%. CONCLUSION: SIS tool is suitable to assess pCRT response both to identify major responders and complete responders in order to guide the surgeon versus more or less conservative treatment.
Authors: N A Janjan; C Crane; B W Feig; K Cleary; R Dubrow; S Curley; J N Vauthey; P Lynch; L M Ellis; R Wolff; R Lenzi; J Abbruzzese; R Pazdur; P M Hoff; P Allen; T Brown; J Skibber Journal: Am J Clin Oncol Date: 2001-04 Impact factor: 2.339
Authors: Monique Maas; Patty J Nelemans; Vincenzo Valentini; Prajnan Das; Claus Rödel; Li-Jen Kuo; Felipe A Calvo; Julio García-Aguilar; Rob Glynne-Jones; Karin Haustermans; Mohammed Mohiuddin; Salvatore Pucciarelli; William Small; Javier Suárez; George Theodoropoulos; Sebastiano Biondo; Regina G H Beets-Tan; Geerard L Beets Journal: Lancet Oncol Date: 2010-08-06 Impact factor: 41.316
Authors: Rodrigo Oliva Perez; Angelita Habr-Gama; Guilherme Pagin São Julião; Igor Proscurshim; Laura Melina Fernandez; Rafael Ulysses de Azevedo; Bruna B Vailati; Felipe Alexandre Fernandes; Joaquim Gama-Rodrigues Journal: Ann Surg Oncol Date: 2015-11-17 Impact factor: 5.344
Authors: Antonella Petrillo; Roberta Fusco; Vincenza Granata; Sergio Venanzio Setola; Mario Sansone; Daniela Rega; Paolo Delrio; Francesco Bianco; Giovanni Maria Romano; Fabiana Tatangelo; Antonio Avallone; Biagio Pecori Journal: Med Oncol Date: 2017-11-18 Impact factor: 3.064
Authors: A Avallone; P Delrio; C Guida; F Tatangelo; A Petrillo; P Marone; L G Cascini; B Morrica; S Lastoria; V Parisi; A Budillon; P Comella Journal: Br J Cancer Date: 2006-05-30 Impact factor: 7.640