Akio Kodama1, Mitsuyoshi Takahara2, Osamu Iida3, Yoshimitsu Soga4, Hiroto Terashi5, Daizo Kawasaki6, Yuichi Izumi7, Shinsuke Mii8, Kimihiro Komori1, Nobuyoshi Azuma9. 1. Division of Vascular Surgery, Department of Surgery, Nagoya University School of Medicine. 2. Department of Diabetes Care Medicine, and Department of Metabolic Medicine, Osaka University Graduate School of Medicine. 3. Cardiovascular Center, Kansai Rosai Hospital. 4. Department of Cardiology, Kokura Memorial Hospital. 5. Department of Plastic Surgery, Kobe University Graduate School of Medicine. 6. Cardiovascular Center, Morinomiya Hospital. 7. Nayoro City General Hospital. 8. Department of Vascular Surgery, Saiseikai Yahata General Hospital. 9. Department of Vascular Surgery, Asahikawa Medical University.
Abstract
AIM: Maintaining functional status through revascularization is a major goal in patients with chronic limb-threatening ischemia (CLTI). Nevertheless, there is a lack of clarity on the impact of revascularization on mobility over time. This study examined ambulatory status over time after revascularization and predictors of ambulation loss in CLTI patients. METHODS: We used a clinical database established by the Surgical reconstruction versus Peripheral INtervention in pAtients with critical limb isCHemia study, a prospective, multicentre, observational study including patients with CLTI. The primary endpoint was mobility over time. RESULTS: Of the 381 patients, the ambulatory proportion at baseline was 71%. The proportion gradually decreased, finally reaching 40% at 36 months. In non-ambulatory patients at revasacularisation, approximately 20-40% of patients achieved ambulation. Multivariate analysis confirmed that age, impaired mobility before CLTI onset and at revascularization, renal failure on dialysis, and WIfI clinical stage 4 were positively associated with ambulation loss at either specific or all time points, whereas male sex and surgical reconstruction were inversely associated with the outcomes at specific time points. CONCLUSION: Mobility in the overall population gradually decreased, whereas the number of deceased patients increased. Advanced age, impaired mobility before CLTI onset and at revascularization, renal failure on dialysis, and WIfI stage 4 were associated with ambulation loss at almost all points after revascularization.
AIM: Maintaining functional status through revascularization is a major goal in patients with chronic limb-threatening ischemia (CLTI). Nevertheless, there is a lack of clarity on the impact of revascularization on mobility over time. This study examined ambulatory status over time after revascularization and predictors of ambulation loss in CLTI patients. METHODS: We used a clinical database established by the Surgical reconstruction versus Peripheral INtervention in pAtients with critical limb isCHemia study, a prospective, multicentre, observational study including patients with CLTI. The primary endpoint was mobility over time. RESULTS: Of the 381 patients, the ambulatory proportion at baseline was 71%. The proportion gradually decreased, finally reaching 40% at 36 months. In non-ambulatory patients at revasacularisation, approximately 20-40% of patients achieved ambulation. Multivariate analysis confirmed that age, impaired mobility before CLTI onset and at revascularization, renal failure on dialysis, and WIfI clinical stage 4 were positively associated with ambulation loss at either specific or all time points, whereas male sex and surgical reconstruction were inversely associated with the outcomes at specific time points. CONCLUSION: Mobility in the overall population gradually decreased, whereas the number of deceased patients increased. Advanced age, impaired mobility before CLTI onset and at revascularization, renal failure on dialysis, and WIfI stage 4 were associated with ambulation loss at almost all points after revascularization.
Authors: Abd Moain Abu Dabrh; Mark W Steffen; Chaitanya Undavalli; Noor Asi; Zhen Wang; Mohamed B Elamin; Michael S Conte; Mohammad Hassan Murad Journal: J Vasc Surg Date: 2015-09-26 Impact factor: 4.268
Authors: Michael S Conte; Andrew W Bradbury; Philippe Kolh; John V White; Florian Dick; Robert Fitridge; Joseph L Mills; Jean-Baptiste Ricco; Kalkunte R Suresh; M Hassan Murad; Victor Aboyans; Murat Aksoy; Vlad-Adrian Alexandrescu; David Armstrong; Nobuyoshi Azuma; Jill Belch; Michel Bergoeing; Martin Bjorck; Nabil Chakfé; Stephen Cheng; Joseph Dawson; Eike S Debus; Andrew Dueck; Susan Duval; Hans H Eckstein; Roberto Ferraresi; Raghvinder Gambhir; Mauro Gargiulo; Patrick Geraghty; Steve Goode; Bruce Gray; Wei Guo; Prem C Gupta; Robert Hinchliffe; Prasad Jetty; Kimihiro Komori; Lawrence Lavery; Wei Liang; Robert Lookstein; Matthew Menard; Sanjay Misra; Tetsuro Miyata; Greg Moneta; Jose A Munoa Prado; Alberto Munoz; Juan E Paolini; Manesh Patel; Frank Pomposelli; Richard Powell; Peter Robless; Lee Rogers; Andres Schanzer; Peter Schneider; Spence Taylor; Melina V De Ceniga; Martin Veller; Frank Vermassen; Jinsong Wang; Shenming Wang Journal: Eur J Vasc Endovasc Surg Date: 2019-06-08 Impact factor: 7.069
Authors: Benjamin D Hunt; Matthew A Popplewell; Huw Davies; Lewis Meecham; Hugh Jarrett; Gareth Bate; Margaret Grant; Smitaa Patel; Catherine Hewitt; Lazaros Andronis; Jonathan J Deeks; Andrew Bradbury Journal: Trials Date: 2017-05-19 Impact factor: 2.279