Marlou-Floor Kenkhuis1, Eline H van Roekel, José J L Breedveld-Peters, Stéphanie O Breukink, Maryska L G Janssen-Heijnen, Eric T P Keulen, Fränzel J B van Duijnhoven, Floortje Mols, Matty P Weijenberg, Martijn J L Bours. 1. Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands Department of Surgery, GROW School for Oncology and Developmental Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, the Netherlands Department of Clinical Epidemiology, Viecuri Medical Center, Venlo, the Netherlands Department of Internal Medicine and Gastroenterology, Zuyderland Medical Centre, Sittard-Geleen, the Netherlands Department of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands.
Abstract
INTRODUCTION: Given the growing population of colorectal cancer (CRC) survivors, identifying ways to enhance health-related quality of life (HRQoL) and alleviate complaints of fatigue and chemotherapy-induced peripheral neuropathy (CIPN) is essential. PURPOSE: We aimed to assess longitudinal associations of sedentary behaviour (SB) and moderate-to-vigorous physical activity (MVPA) independently, as well as their joint association, with HRQoL, fatigue and CIPN in CRC survivors. METHODS: In a prospective cohort among stage I-III CRC survivors (n = 396), five repeated home visits from diagnosis up to 24 months post-treatment were executed. SB was measured using tri-axial accelerometers, and MVPA, HRQoL, fatigue and CIPN were measured by validated questionnaires. We applied confounder-adjusted linear mixed-models to analyse longitudinal associations from 6 weeks until 24 months post-treatment. RESULTS: Average time in prolonged SB (accumulated in bouts of duration ≥30 minutes) was 5.3 (SD: 2.7) hours·day-1 and approximately 82% of survivors were classified as sufficiently active (≥150 minutes·week-1 of MVPA) at 6 weeks post-treatment. Decreases in SB and increases in MVPA were independently associated with better HRQoL and less fatigue over time. No associations were found for CIPN complaints. A synergistic interaction was observed between prolonged SB and MVPA in affecting functioning scales. Relative to CRC survivors with low prolonged SB and high MVPA, survivors with high prolonged SB and low MVPA reported a stronger decrease in physical functioning and role functioning over time than expected based on the independent associations of prolonged SB and MVPA. CONCLUSION: Our longitudinal results show that less SB and more MVPA are beneficial for CRC survivors' HRQoL and fatigue levels. Our findings regarding interaction underscore that joint recommendations to avoid prolonged sitting and accumulate MVPA is important.
INTRODUCTION: Given the growing population of colorectal cancer (CRC) survivors, identifying ways to enhance health-related quality of life (HRQoL) and alleviate complaints of fatigue and chemotherapy-induced peripheral neuropathy (CIPN) is essential. PURPOSE: We aimed to assess longitudinal associations of sedentary behaviour (SB) and moderate-to-vigorous physical activity (MVPA) independently, as well as their joint association, with HRQoL, fatigue and CIPN in CRC survivors. METHODS: In a prospective cohort among stage I-III CRC survivors (n = 396), five repeated home visits from diagnosis up to 24 months post-treatment were executed. SB was measured using tri-axial accelerometers, and MVPA, HRQoL, fatigue and CIPN were measured by validated questionnaires. We applied confounder-adjusted linear mixed-models to analyse longitudinal associations from 6 weeks until 24 months post-treatment. RESULTS: Average time in prolonged SB (accumulated in bouts of duration ≥30 minutes) was 5.3 (SD: 2.7) hours·day-1 and approximately 82% of survivors were classified as sufficiently active (≥150 minutes·week-1 of MVPA) at 6 weeks post-treatment. Decreases in SB and increases in MVPA were independently associated with better HRQoL and less fatigue over time. No associations were found for CIPN complaints. A synergistic interaction was observed between prolonged SB and MVPA in affecting functioning scales. Relative to CRC survivors with low prolonged SB and high MVPA, survivors with high prolonged SB and low MVPA reported a stronger decrease in physical functioning and role functioning over time than expected based on the independent associations of prolonged SB and MVPA. CONCLUSION: Our longitudinal results show that less SB and more MVPA are beneficial for CRC survivors' HRQoL and fatigue levels. Our findings regarding interaction underscore that joint recommendations to avoid prolonged sitting and accumulate MVPA is important.
Authors: Martijn J L Bours; Eline H van Roekel; Marlou-Floor Kenkhuis; Mo Klingestijn; Anne-Marie Fanshawe; Stéphanie O Breukink; Maryska L G Janssen-Heijnen; Eric T P Keulen; Sabina Rinaldi; Paolo Vineis; Marc J Gunter; Michael F Leitzmann; Augustin Scalbert; Matty P Weijenberg Journal: J Cancer Res Clin Oncol Date: 2022-08-30 Impact factor: 4.322
Authors: Marlou-Floor Kenkhuis; Floortje Mols; Eline H van Roekel; José J L Breedveld-Peters; Stéphanie O Breukink; Maryska L G Janssen-Heijnen; Eric T P Keulen; Fränzel J B van Duijnhoven; Matty P Weijenberg; Martijn J L Bours Journal: Cancers (Basel) Date: 2022-01-14 Impact factor: 6.639