Sonya S Kaur1,2, Wassim Tarraf3, Benson Wu4, Kevin A Gonzalez4, Martha Daviglus5, Neomi Shah6, Daniela Sotres-Alvarez7, Linda C Gallo8, William Wohlgemuth9, Susan Redline10, Hector M Gonzalez4, Alberto R Ramos1,2. 1. University of Miami Miller School of Medicine, Miami, Florida, USA. 2. Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, Florida, USA. 3. Wayne State University, Detroit, Michigan, USA. 4. University of California San Diego, San Diego, California, USA. 5. University of Illinois at Chicago, Chicago, Illinois, USA. 6. Mount Sinai Icahn School of Medicine, New York, New York, USA. 7. University of North Carolina at Chapel Hill, North Carolina, USA. 8. San Diego State University, San Diego, California, USA. 9. Miami Veterans Association Medical Center, Miami, Florida, USA. 10. Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Abstract
INTRODUCTION: We aimed to determine whether obesity or metabolic syndrome (MetS) modify associations between sleep-disordered breathing (SDB), self-reported sleep duration (SD), and phenotypes of combined SDB/SD with 7-year neurocognitive decline (ND) in a community based-cohort of U.S. Hispanic/Latinos (N = 5500) in different age and sex groups. METHODS: The exposures were baseline SDB (respiratory event index ≥ 15), sleepiness (Epworth Sleepiness Scale ≥ 10), SD (< 6 hours, 6-9 hours, ≥ 9 hours). The outcome was 7-year ND. RESULTS: Mean age was 56.0 years, 54.8% were females. Obesity modified the association between SDB/SD and ND in memory (F = 21.49, P < 0.001) and global cognition (F = 9.14, P < 0.001) in the oldest age group. Women without MetS with combined long sleep/SDB exhibited most pronounced decline in global cognition (F = 3.07, P = 0.010). DISCUSSION: The association between combined SDB/long sleep and declines in memory and global cognition was most pronounced in obese older adults. Among women, MetS status modified the association between long sleep/SDB and decline in global cognition.
INTRODUCTION: We aimed to determine whether obesity or metabolic syndrome (MetS) modify associations between sleep-disordered breathing (SDB), self-reported sleep duration (SD), and phenotypes of combined SDB/SD with 7-year neurocognitive decline (ND) in a community based-cohort of U.S. Hispanic/Latinos (N = 5500) in different age and sex groups. METHODS: The exposures were baseline SDB (respiratory event index ≥ 15), sleepiness (Epworth Sleepiness Scale ≥ 10), SD (< 6 hours, 6-9 hours, ≥ 9 hours). The outcome was 7-year ND. RESULTS: Mean age was 56.0 years, 54.8% were females. Obesity modified the association between SDB/SD and ND in memory (F = 21.49, P < 0.001) and global cognition (F = 9.14, P < 0.001) in the oldest age group. Women without MetS with combined long sleep/SDB exhibited most pronounced decline in global cognition (F = 3.07, P = 0.010). DISCUSSION: The association between combined SDB/long sleep and declines in memory and global cognition was most pronounced in obese older adults. Among women, MetS status modified the association between long sleep/SDB and decline in global cognition.
Authors: Wendy M Troxel; Daniel J Buysse; Karen A Matthews; Kevin E Kip; Patrick J Strollo; Martica Hall; Oliver Drumheller; Steven E Reis Journal: Sleep Date: 2010-12 Impact factor: 5.849
Authors: Kristine Yaffe; Alka Kanaya; Karla Lindquist; Eleanor M Simonsick; Tamara Harris; Ronald I Shorr; Frances A Tylavsky; Anne B Newman Journal: JAMA Date: 2004-11-10 Impact factor: 56.272
Authors: Sanjay R Patel; Daniela Sotres-Alvarez; Sheila F Castañeda; Katherine A Dudley; Linda C Gallo; Rosalba Hernandez; Elizabeth A Medeiros; Frank J Penedo; Yasmin Mossavar-Rahmani; Alberto R Ramos; Susan Redline; Kathryn J Reid; Phyllis C Zee Journal: Sleep Date: 2015-10-01 Impact factor: 5.849
Authors: Naresh M Punjabi; Eyal Shahar; Susan Redline; Daniel J Gottlieb; Rachel Givelber; Helaine E Resnick Journal: Am J Epidemiol Date: 2004-09-15 Impact factor: 4.897
Authors: Kristin J Addison-Brown; Abraham J Letter; Klar Yaggi; Leslie A McClure; Frederick W Unverzagt; Virginia J Howard; Judith H Lichtman; Virginia G Wadley Journal: J Sleep Res Date: 2013-09-02 Impact factor: 3.981
Authors: Alberto R Ramos; Hannah Gardener; Tatjana Rundek; Mitchell S V Elkind; Bernadette Boden-Albala; Chuanhui Dong; Ying Kuen Cheung; Yaakov Stern; Ralph L Sacco; Clinton B Wright Journal: Neurology Date: 2016-09-02 Impact factor: 9.910
Authors: Auriel A Willette; Guofan Xu; Sterling C Johnson; Alex C Birdsill; Erin M Jonaitis; Mark A Sager; Bruce P Hermann; Asenath La Rue; Sanjay Asthana; Barbara B Bendlin Journal: Diabetes Care Date: 2012-10-15 Impact factor: 19.112