Literature DB >> 34029863

The effects of education on cognition in older age: Evidence from genotyped Siblings.

Jason Fletcher1, Michael Topping2, Fengyi Zheng3, Qiongshi Lu4.   

Abstract

A growing literature has sought to tie educational attainment with later-life cognition and Alzheimer's disease outcomes. This paper leverages sibling comparisons in educational attainment as well as genetic predictors (polygenic scores) for cognition, educational attainment, and Alzheimer's disease to estimate effects of educational attainment on cognition in older age in the United Kingdom. We find that the effects of education on cognition are confounded by family background factors (~40%) and by genetics (<10%). After adjustments, we continue to find large effects of education. College graduates have cognition scores that are approximately 0.75 SD higher than those who report no credentials. We also find evidence that educational effects on cognition are smaller for those with high polygenic scores for Alzheimer's disease.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Education; Gene-environment interactions; Old age cognition; Sibling fixed effects; UK Biobank

Mesh:

Year:  2021        PMID: 34029863      PMCID: PMC8205990          DOI: 10.1016/j.socscimed.2021.114044

Source DB:  PubMed          Journal:  Soc Sci Med        ISSN: 0277-9536            Impact factor:   5.379


  49 in total

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