| Literature DB >> 34029863 |
Jason Fletcher1, Michael Topping2, Fengyi Zheng3, Qiongshi Lu4.
Abstract
A growing literature has sought to tie educational attainment with later-life cognition and Alzheimer's disease outcomes. This paper leverages sibling comparisons in educational attainment as well as genetic predictors (polygenic scores) for cognition, educational attainment, and Alzheimer's disease to estimate effects of educational attainment on cognition in older age in the United Kingdom. We find that the effects of education on cognition are confounded by family background factors (~40%) and by genetics (<10%). After adjustments, we continue to find large effects of education. College graduates have cognition scores that are approximately 0.75 SD higher than those who report no credentials. We also find evidence that educational effects on cognition are smaller for those with high polygenic scores for Alzheimer's disease.Entities:
Keywords: Education; Gene-environment interactions; Old age cognition; Sibling fixed effects; UK Biobank
Mesh:
Year: 2021 PMID: 34029863 PMCID: PMC8205990 DOI: 10.1016/j.socscimed.2021.114044
Source DB: PubMed Journal: Soc Sci Med ISSN: 0277-9536 Impact factor: 5.379