Literature DB >> 34027050

Regulation of autophagy by VPS34 branched ubiquitination controls proteostasis and liver metabolism.

Yu-Hsuan Chen1, Ruey-Hwa Chen1.   

Abstract

Ubiquitin-proteasome system and autophagy are the two major recycling processes. Our recent work uncovers a K29/K48 branched ubiquitination on the phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3, best known as VPS34). This ubiquitination is positively or negatively regulated under pathophysiological conditions to influence on autophagy, proteostasis and lipid homeostasis.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Autophagy; branched ubiquitination; liver steatosis; protein quality control; vps34

Year:  2021        PMID： 34027050      PMCID： PMC8128189          DOI： 10.1080/23723556.2021.1915076

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates.

Authors:  Bernard W Chu; Kyle M Kovary; Johan Guillaume; Ling-chun Chen; Mary N Teruel; Thomas J Wandless
Journal:  J Biol Chem       Date:  2013-10-24       Impact factor: 5.157

2.  A versatile synthetic dimerizer for the regulation of protein-protein interactions.

Authors:  J F Amara; T Clackson; V M Rivera; T Guo; T Keenan; S Natesan; R Pollock; W Yang; N L Courage; D A Holt; M Gilman
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

Review 3.  The increasing complexity of the ubiquitin code.

Authors:  Richard Yau; Michael Rape
Journal:  Nat Cell Biol       Date:  2016-05-27       Impact factor: 28.824

4.  Insights into ubiquitin chain architecture using Ub-clipping.

Authors:  Kirby N Swatek; Joanne L Usher; Anja F Kueck; Christina Gladkova; Tycho E T Mevissen; Jonathan N Pruneda; Tim Skern; David Komander
Journal:  Nature       Date:  2019-08-15       Impact factor: 49.962

5.  A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

Authors:  Ming Xu; Brian Skaug; Wenwen Zeng; Zhijian J Chen
Journal:  Mol Cell       Date:  2009-10-23       Impact factor: 17.970

6.  An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.

Authors:  Julien D F Licchesi; Juliusz Mieszczanek; Tycho E T Mevissen; Trevor J Rutherford; Masato Akutsu; Satpal Virdee; Farid El Oualid; Jason W Chin; Huib Ovaa; Mariann Bienz; David Komander
Journal:  Nat Struct Mol Biol       Date:  2011-12-11       Impact factor: 15.369

Review 7.  Ubiquitin-mediated regulation of autophagy.

Authors:  Ruey-Hwa Chen; Yu-Hsuan Chen; Tzu-Yu Huang
Journal:  J Biomed Sci       Date:  2019-10-21       Impact factor: 8.410

Review 8.  Branched Ubiquitination: Detection Methods, Biological Functions and Chemical Synthesis.

Authors:  Yane-Shih Wang; Kuen-Phon Wu; Han-Kai Jiang; Prashant Kurkute; Ruey-Hwa Chen
Journal:  Molecules       Date:  2020-11-09       Impact factor: 4.411

9.  VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism.

Authors:  Yu-Hsuan Chen; Tzu-Yu Huang; Yu-Tung Lin; Shu-Yu Lin; Wen-Hsin Li; Hsiang-Jung Hsiao; Ruei-Liang Yan; Hong-Wen Tang; Zhao-Qing Shen; Guang-Chao Chen; Kuen-Phon Wu; Ting-Fen Tsai; Ruey-Hwa Chen
Journal:  Nat Commun       Date:  2021-02-26       Impact factor: 14.919

10.  Enhanced protein degradation by branched ubiquitin chains.

Authors:  Hermann-Josef Meyer; Michael Rape
Journal:  Cell       Date:  2014-05-08       Impact factor: 41.582
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.