Literature DB >> 27230526

The increasing complexity of the ubiquitin code.

Richard Yau1,2, Michael Rape1,2.   

Abstract

Ubiquitylation is essential for signal transduction as well as cell division and differentiation in all eukaryotes. Substrate modifications range from a single ubiquitin molecule to complex polymeric chains, with different types of ubiquitylation often eliciting distinct outcomes. The recent identification of novel chain topologies has improved our understanding of how ubiquitylation establishes precise communication within cells. Here, we discuss how the increasing complexity of ubiquitylation is employed to ensure robust and faithful signal transduction in eukaryotic cells.

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Year:  2016        PMID： 27230526     DOI： 10.1038/ncb3358

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  150 in total

1.  A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

Authors:  M Koegl; T Hoppe; S Schlenker; H D Ulrich; T U Mayer; S Jentsch
Journal:  Cell       Date:  1999-03-05       Impact factor: 41.582

2.  The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification.

Authors:  Hikaru Tsuchiya; Keiji Tanaka; Yasushi Saeki
Journal:  Biochem Biophys Res Commun       Date:  2013-05-31       Impact factor: 3.575

3.  Ubiquitin is phosphorylated by PINK1 to activate parkin.

Authors:  Fumika Koyano; Kei Okatsu; Hidetaka Kosako; Yasushi Tamura; Etsu Go; Mayumi Kimura; Yoko Kimura; Hikaru Tsuchiya; Hidehito Yoshihara; Takatsugu Hirokawa; Toshiya Endo; Edward A Fon; Jean-François Trempe; Yasushi Saeki; Keiji Tanaka; Noriyuki Matsuda
Journal:  Nature       Date:  2014-06-04       Impact factor: 49.962

4.  Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

Authors:  Elena Maspero; Eleonora Valentini; Sara Mari; Valentina Cecatiello; Paolo Soffientini; Sebastiano Pasqualato; Simona Polo
Journal:  Nat Struct Mol Biol       Date:  2013-05-05       Impact factor: 15.369

5.  Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

Authors:  Klarisa Rikova; Ailan Guo; Qingfu Zeng; Anthony Possemato; Jian Yu; Herbert Haack; Julie Nardone; Kimberly Lee; Cynthia Reeves; Yu Li; Yerong Hu; Zhiping Tan; Matthew Stokes; Laura Sullivan; Jeffrey Mitchell; Randy Wetzel; Joan Macneill; Jian Min Ren; Jin Yuan; Corey E Bakalarski; Judit Villen; Jon M Kornhauser; Bradley Smith; Daiqiang Li; Xinmin Zhou; Steven P Gygi; Ting-Lei Gu; Roberto D Polakiewicz; John Rush; Michael J Comb
Journal:  Cell       Date:  2007-12-14       Impact factor: 41.582

6.  Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.

Authors:  Emma Branigan; Anna Plechanovová; Ellis G Jaffray; James H Naismith; Ronald T Hay
Journal:  Nat Struct Mol Biol       Date:  2015-07-06       Impact factor: 15.369

7.  OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

Authors:  Tycho E T Mevissen; Manuela K Hospenthal; Paul P Geurink; Paul R Elliott; Masato Akutsu; Nadia Arnaudo; Reggy Ekkebus; Yogesh Kulathu; Tobias Wauer; Farid El Oualid; Stefan M V Freund; Huib Ovaa; David Komander
Journal:  Cell       Date:  2013-07-03       Impact factor: 41.582

8.  K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.

Authors:  Yosua Adi Kristariyanto; Syed Arif Abdul Rehman; David G Campbell; Nicholas A Morrice; Clare Johnson; Rachel Toth; Yogesh Kulathu
Journal:  Mol Cell       Date:  2015-03-05       Impact factor: 17.970

9.  RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.

Authors:  Yue Qin; Mao-Tian Zhou; Ming-Ming Hu; Yun-Hong Hu; Jing Zhang; Lin Guo; Bo Zhong; Hong-Bing Shu
Journal:  PLoS Pathog       Date:  2014-09-25       Impact factor: 6.823

10.  Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Authors:  Yu Ye; Georg Blaser; Mathew H Horrocks; Maria J Ruedas-Rama; Shehu Ibrahim; Alexander A Zhukov; Angel Orte; David Klenerman; Sophie E Jackson; David Komander
Journal:  Nature       Date:  2012-12-02       Impact factor: 49.962
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  321 in total

Review 1.  Preclinical and Clinical Advances of Targeted Protein Degradation as a Novel Cancer Therapeutic Strategy: An Oncologist Perspective.

Authors:  Xinrui Yang; He Yin; Richard D Kim; Jason B Fleming; Hao Xie
Journal:  Target Oncol       Date:  2020-12-28       Impact factor: 4.493

Review 2.  Beyond Mitophagy: The Diversity and Complexity of Parkin Function.

Authors:  Sarah E Shires; Richard N Kitsis; Åsa B Gustafsson
Journal:  Circ Res       Date:  2017-04-14       Impact factor: 17.367

3.  K63-Linked Ubiquitin Is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus TRIM5α.

Authors:  Sabrina Imam; Sevnur Kömürlü; Jessica Mattick; Anastasia Selyutina; Sarah Talley; Amani Eddins; Felipe Diaz-Griffero; Edward M Campbell
Journal:  J Virol       Date:  2019-06-28       Impact factor: 5.103

4.  Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.

Authors:  Jara K Brenke; Grzegorz M Popowicz; Kenji Schorpp; Ina Rothenaigner; Manfred Roesner; Isabel Meininger; Cédric Kalinski; Larissa Ringelstetter; Omar R'kyek; Gerrit Jürjens; Michelle Vincendeau; Oliver Plettenburg; Michael Sattler; Daniel Krappmann; Kamyar Hadian
Journal:  J Biol Chem       Date:  2018-06-27       Impact factor: 5.157

5.  OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.

Authors:  Yu Zhao; Miranda C Mudge; Jennifer M Soll; Rachel B Rodrigues; Andrea K Byrum; Elizabeth A Schwarzkopf; Tara R Bradstreet; Steven P Gygi; Brian T Edelson; Nima Mosammaparast
Journal:  Mol Cell       Date:  2018-02-01       Impact factor: 17.970

6.  Exploring the Functional Consequences of Protein Backbone Alteration in Ubiquitin through Native Chemical Ligation.

Authors:  Halina M Werner; Samuel K Estabrooks; G Michael Preston; Jeffrey L Brodsky; W Seth Horne
Journal:  Chembiochem       Date:  2019-08-23       Impact factor: 3.164

Review 7.  Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope.

Authors:  Adrian B Mehrtash; Mark Hochstrasser
Journal:  Semin Cell Dev Biol       Date:  2018-10-09       Impact factor: 7.727

8.  Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity.

Authors:  Zongyang Lv; Katelyn M Williams; Lingmin Yuan; James H Atkison; Shaun K Olsen
Journal:  J Biol Chem       Date:  2018-10-02       Impact factor: 5.157

9.  Site-Specific K63 Ubiquitinomics Provides Insights into Translation Regulation under Stress.

Authors:  Songhee Back; Andrew W Gorman; Christine Vogel; Gustavo M Silva
Journal:  J Proteome Res       Date:  2018-12-10       Impact factor: 4.466

10.  The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.

Authors:  Teresa M Buck; Xuemei Zeng; Pamela S Cantrell; Richard T Cattley; Zikri Hasanbasri; Megan E Yates; Diep Nguyen; Nathan A Yates; Jeffrey L Brodsky
Journal:  Mol Cell Proteomics       Date:  2020-08-31       Impact factor: 5.911
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