Literature DB >> 34027046

A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.

Belen Gómez-González1,2, Gaetana Sessa3,4, Aura Carreira3,4, Andrés Aguilera1,2.   

Abstract

In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2T2 07A missense variant found in breast cancer patients.
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Entities:  

Keywords:  BRCA2; DDX5; DNA-RNA hybrid; DSB repair; breast cancer; double-strand break; homologous recombination

Year:  2021        PMID： 34027046      PMCID： PMC8128217          DOI： 10.1080/23723556.2021.1910474

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

Authors:  Vaibhav Bhatia; Sonia I Barroso; María L García-Rubio; Emanuela Tumini; Emilia Herrera-Moyano; Andrés Aguilera
Journal:  Nature       Date:  2014-06-01       Impact factor: 49.962

2.  DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells.

Authors:  Anthony Mazurek; Weijun Luo; Alexander Krasnitz; James Hicks; R Scott Powers; Bruce Stillman
Journal:  Cancer Discov       Date:  2012-06-29       Impact factor: 39.397

Review 3.  Molding BRCA2 function through its interacting partners.

Authors:  Juan S Martinez; Céline Baldeyron; Aura Carreira
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

4.  DNA-RNA hybrids: the risks of DNA breakage during transcription.

Authors:  Andrés Aguilera; Belén Gómez-González
Journal:  Nat Struct Mol Biol       Date:  2017-05-04       Impact factor: 15.369

5.  BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡.

Authors:  Gaetana Sessa; Belén Gómez-González; Sonia Silva; Carmen Pérez-Calero; Romane Beaurepere; Sonia Barroso; Sylvain Martineau; Charlotte Martin; Åsa Ehlén; Juan S Martínez; Bérangère Lombard; Damarys Loew; Stephan Vagner; Andrés Aguilera; Aura Carreira
Journal:  EMBO J       Date:  2021-02-26       Impact factor: 11.598

6.  DNA double strand break repair pathway choice: a chromatin based decision?

Authors:  T Clouaire; G Legube
Journal:  Nucleus       Date:  2015-02-12       Impact factor: 4.197

7.  BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment.

Authors:  Giuseppina D'Alessandro; Donna Rose Whelan; Sean Michael Howard; Valerio Vitelli; Xavier Renaudin; Marek Adamowicz; Fabio Iannelli; Corey Winston Jones-Weinert; MiYoung Lee; Valentina Matti; Wei Ting C Lee; Michael John Morten; Ashok Raraakrishnan Venkitaraman; Petr Cejka; Eli Rothenberg; Fabrizio d'Adda di Fagagna
Journal:  Nat Commun       Date:  2018-12-18       Impact factor: 14.919

8.  Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids.

Authors:  Sofiane Y Mersaoui; Zhenbao Yu; Yan Coulombe; Martin Karam; Franciele F Busatto; Jean-Yves Masson; Stéphane Richard
Journal:  EMBO J       Date:  2019-06-21       Impact factor: 11.598

9.  Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.

Authors:  Charlotte Martin; Simona Miron; Manon Julien; Åsa Ehlén; François-Xavier Theillet; Virginie Ropars; Gaetana Sessa; Romane Beaurepere; Virginie Boucherit; Patricia Duchambon; Ahmed El Marjou; Sophie Zinn-Justin; Aura Carreira
Journal:  Nat Commun       Date:  2020-04-14       Impact factor: 14.919
  10 in total
  1 in total

Review 1.  Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.

Authors:  Eva Petermann; Li Lan; Lee Zou
Journal:  Nat Rev Mol Cell Biol       Date:  2022-04-22       Impact factor: 113.915
  1 in total

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