Literature DB >> 34017045

Wnt signaling in lung development, regeneration, and disease progression.

Cody J Aros1,2,3, Carla J Pantoja3, Brigitte N Gomperts4,5,6,7.   

Abstract

The respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling pathway plays several crucial and indispensable roles across lung biology in multiple contexts. This review highlights the progress made in characterizing the role of Wnt signaling across several disciplines in lung biology, including development, homeostasis, regeneration following injury, in vitro directed differentiation efforts, and disease progression. We further note uncharted directions in the field that may illuminate important biology. The discoveries made collectively advance our understanding of Wnt signaling in lung biology and have the potential to inform therapeutic advancements for lung diseases.

Entities:  

Mesh：

Year:  2021        PMID： 34017045      PMCID： PMC8138018          DOI： 10.1038/s42003-021-02118-w

Source DB:  PubMed          Journal:  Commun Biol        ISSN： 2399-3642


  142 in total

1.  Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction.

Authors:  Qiaozhen Liu; Kuo Liu; Guizhong Cui; Xiuzhen Huang; Shun Yao; Wenke Guo; Zhen Qin; Yan Li; Rui Yang; Wenjuan Pu; Libo Zhang; Lingjuan He; Huan Zhao; Wei Yu; Muxue Tang; Xueying Tian; Dongqing Cai; Yu Nie; Shengshou Hu; Tao Ren; Zengyong Qiao; Hefeng Huang; Yi Arial Zeng; Naihe Jing; Guangdun Peng; Hongbin Ji; Bin Zhou
Journal:  Nat Genet       Date:  2019-02-18       Impact factor: 38.330

2.  Notum attenuates Wnt/β-catenin signaling to promote tracheal cartilage patterning.

Authors:  Bradley Gerhardt; Lauren Leesman; Kaulini Burra; John Snowball; Rachel Rosenzweig; Natalie Guzman; Manoj Ambalavanan; Debora Sinner
Journal:  Dev Biol       Date:  2018-02-09       Impact factor: 3.582

3.  Hyperoxia Injury in the Developing Lung Is Mediated by Mesenchymal Expression of Wnt5A.

Authors:  Jennifer M S Sucre; Kasey C Vickers; John T Benjamin; Erin J Plosa; Christopher S Jetter; Alissa Cutrone; Meaghan Ransom; Zachary Anderson; Quanhu Sheng; Benjamin A Fensterheim; Namasivayam Ambalavanan; Bryan Millis; Ethan Lee; Andries Zijlstra; Melanie Königshoff; Timothy S Blackwell; Susan H Guttentag
Journal:  Am J Respir Crit Care Med       Date:  2020-05-15       Impact factor: 21.405

4.  Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.

Authors:  Jared J Barrott; Gabriela M Cash; Aaron P Smith; Jeffery R Barrow; L Charles Murtaugh
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-18       Impact factor: 11.205

5.  Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells.

Authors:  Alexandros Strikoudis; Anna Cieślak; Lucas Loffredo; Ya-Wen Chen; Nina Patel; Anjali Saqi; David J Lederer; Hans-Willem Snoeck
Journal:  Cell Rep       Date:  2019-06-18       Impact factor: 9.423

6.  beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium.

Authors:  Anna C Zemke; Roxana M Teisanu; Adam Giangreco; Jeff A Drake; Brian L Brockway; Susan D Reynolds; Barry R Stripp
Journal:  Am J Respir Cell Mol Biol       Date:  2009-02-12       Impact factor: 6.914

7.  The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.

Authors:  Emma L Rawlins; Tadashi Okubo; Yan Xue; David M Brass; Richard L Auten; Hiroshi Hasegawa; Fan Wang; Brigid L M Hogan
Journal:  Cell Stem Cell       Date:  2009-06-05       Impact factor: 24.633

8.  beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis.

Authors:  Michael L Mucenski; Susan E Wert; Jennifer M Nation; David E Loudy; Joerg Huelsken; Walter Birchmeier; Edward E Morrisey; Jeffrey A Whitsett
Journal:  J Biol Chem       Date:  2003-07-28       Impact factor: 5.157

9.  Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells.

Authors:  Mareike Lehmann; Qianjiang Hu; Yan Hu; Kathrin Hafner; Rita Costa; Anastasia van den Berg; Melanie Königshoff
Journal:  Cell Signal       Date:  2020-02-26       Impact factor: 4.315

10.  Functional Wnt signaling is increased in idiopathic pulmonary fibrosis.

Authors:  Melanie Königshoff; Nisha Balsara; Eva-Maria Pfaff; Monika Kramer; Izabella Chrobak; Werner Seeger; Oliver Eickelberg
Journal:  PLoS One       Date:  2008-05-14       Impact factor: 3.240
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  10 in total

1.  Sox9 and Lef1 Regulate the Fate and Behavior of Airway Glandular Progenitors in Response to Injury.

Authors:  Vitaly Ievlev; Chandler C Jensen-Cody; Thomas J Lynch; Albert C Pai; Soo Park; Weam Shahin; Kai Wang; Kalpaj R Parekh; John F Engelhardt
Journal:  Stem Cells       Date:  2022-08-25       Impact factor: 5.845

Review 2.  Impaired Alveolar Re-Epithelialization in Pulmonary Emphysema.

Authors:  Chih-Ru Lin; Karim Bahmed; Beata Kosmider
Journal:  Cells       Date:  2022-06-28       Impact factor: 7.666

Review 3.  TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer.

Authors:  Aina Martín-Medina; Noemi Cerón-Pisa; Esther Martinez-Font; Hanaa Shafiek; Antònia Obrador-Hevia; Jaume Sauleda; Amanda Iglesias
Journal:  Int J Mol Sci       Date:  2022-06-11       Impact factor: 6.208

Review 4.  Developmental Pathways Underlying Lung Development and Congenital Lung Disorders.

Authors:  Inês Caldeira; Hugo Fernandes-Silva; Daniela Machado-Costa; Jorge Correia-Pinto; Rute Silva Moura
Journal:  Cells       Date:  2021-11-02       Impact factor: 6.600

5.  The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation.

Authors:  Manish Bodas; Bharathiraja Subramaniyan; Andrew R Moore; Jordan P Metcalf; Sarah R Ocañas; Willard M Freeman; Constantin Georgescu; Jonathan D Wren; Matthew S Walters
Journal:  Cells       Date:  2021-11-18       Impact factor: 7.666

Review 6.  Alveologenesis: What Governs Secondary Septa Formation.

Authors:  Alexandra L Rippa; Elena V Alpeeva; Andrey V Vasiliev; Ekaterina A Vorotelyak
Journal:  Int J Mol Sci       Date:  2021-11-09       Impact factor: 5.923

7.  Targeting Interleukin-10 Restores Graft Microvascular Supply and Airway Epithelium in Rejecting Allografts.

Authors:  Shadab Kazmi; Mohammad Afzal Khan; Talal Shamma; Abdullah Altuhami; Hala Abdalrahman Ahmed; Abdullah Mohammed Assiri; Dieter Clemens Broering
Journal:  Int J Mol Sci       Date:  2022-01-23       Impact factor: 5.923

8.  Neonatal lung-derived SSEA-1+ cells exhibited distinct stem/progenitor characteristics and organoid developmental potential.

Authors:  Chien-Chia Liao; Chiao-Juno Chiu; Yao-Hsu Yang; Bor-Luen Chiang
Journal:  iScience       Date:  2022-04-16

9.  Modeling lung diseases using reversibly immortalized mouse pulmonary alveolar type 2 cells (imPAC2).

Authors:  Linghuan Zhang; Wenping Luo; Jiang Liu; Maozhu Xu; Qi Peng; Wenjing Zou; Jingyi You; Yi Shu; Piao Zhao; William Wagstaff; Guozhi Zhao; Kevin Qin; Rex C Haydon; Hue H Luu; Russell R Reid; Yang Bi; Tianyu Zhao; Tong-Chuan He; Zhou Fu
Journal:  Cell Biosci       Date:  2022-09-22       Impact factor: 9.584

Review 10.  Emerging Roles of Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis.

Authors:  Ashesh Chakraborty; Michal Mastalerz; Meshal Ansari; Herbert B Schiller; Claudia A Staab-Weijnitz
Journal:  Cells       Date:  2022-03-19       Impact factor: 6.600
  10 in total

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