| Literature DB >> 30778223 |
Qiaozhen Liu1,2, Kuo Liu1, Guizhong Cui1, Xiuzhen Huang1,2, Shun Yao1, Wenke Guo1,3, Zhen Qin1, Yan Li1,2, Rui Yang1,2, Wenjuan Pu1,2, Libo Zhang1, Lingjuan He1,2, Huan Zhao1,2, Wei Yu1,2, Muxue Tang1,4, Xueying Tian5, Dongqing Cai5, Yu Nie6, Shengshou Hu6, Tao Ren7, Zengyong Qiao8, Hefeng Huang9, Yi Arial Zeng1, Naihe Jing1,3, Guangdun Peng10,11,12,13, Hongbin Ji14,15, Bin Zhou16,17,18,19,20,21.
Abstract
Characterizing the stem cells responsible for lung repair and regeneration is important for the treatment of pulmonary diseases. Recently, a unique cell population located at the bronchioalveolar-duct junctions has been proposed to comprise endogenous stem cells for lung regeneration. However, the role of bronchioalveolar stem cells (BASCs) in vivo remains debated, and the contribution of such cells to lung regeneration is not known. Here we generated a genetic lineage-tracing system that uses dual recombinases (Cre and Dre) to specifically track BASCs in vivo. Fate-mapping and clonal analysis showed that BASCs became activated and responded distinctly to different lung injuries, and differentiated into multiple cell lineages including club cells, ciliated cells, and alveolar type 1 and type 2 cells for lung regeneration. This study provides in vivo genetic evidence that BASCs are bona fide lung epithelial stem cells with deployment of multipotency and self-renewal during lung repair and regeneration.Entities:
Mesh：
Year: 2019 PMID： 30778223 DOI： 10.1038/s41588-019-0346-6
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330