Sujata Deshpande1, Pradeep Suryawanshi2, Shrikant Holkar1, Yogen Singh3, Rameshwor Yengkhom1, Jan Klimek4, Samir Gupta5,6. 1. Department of Neonatology, Bharati Vidyapeeth University Medical College and Hospital, Dhankawadi, Pune, 411043, India. 2. Department of Neonatology, Bharati Vidyapeeth University Medical College and Hospital, Dhankawadi, Pune, 411043, India. drpradeepsuryawanshi@gmail.com. 3. Cambridge University Hospitals, Cambridge, United Kingdom. 4. Westmead Hospital, Westmead, Australia. 5. Division of Neonatology, Sidra Medicine, Doha, Qatar. 6. Durham University, Durham, United Kingdom.
Abstract
PURPOSE: Pulmonary hypertension (PH) in the newborn period is associated with significant morbidity and mortality. Sepsis has been identified as an independent risk factor for PH in newborns. Data on the proportion and severity of PH in association with neonatal sepsis are scarce. This study was aimed to measure the pulmonary artery systolic pressure (PASP) in neonates with late onset sepsis (LOS) and to estimate the proportion of PH in neonatal sepsis using functional echocardiography (FnECHO). METHODS: This prospective observational study was conducted at a tertiary neonatal intensive care unit (NICU). All neonates admitted in the NICU with suspected LOS underwent FnECHO within 6 hours of onset of clinical signs and PASP was recorded. Pulmonary hypertension was defined as PASP of > 35 mmHg. PASP of neonates with positive culture results (proven LOS) was compared with that of gestational age-matched stable controls without sepsis. RESULTS: Thirty three neonates with proven LOS were analysed (study group). Sixteen neonates (49%) in the study group had PH. Mean PASP of the study group was significantly higher than that of the control group (35.3 ± 10.13 mmHg and 12.58 ± 3.92 mmHg, respectively; P < 0.0001). None of the neonates in the control group had PH. CONCLUSION: Pulmonary artery pressure was higher in neonates with late onset neonatal sepsis as compared to that of stable babies without sepsis. Pulmonary hypertension was seen in nearly half of term as well as preterm neonates with late onset sepsis.
PURPOSE: Pulmonary hypertension (PH) in the newborn period is associated with significant morbidity and mortality. Sepsis has been identified as an independent risk factor for PH in newborns. Data on the proportion and severity of PH in association with neonatal sepsis are scarce. This study was aimed to measure the pulmonary artery systolic pressure (PASP) in neonates with late onset sepsis (LOS) and to estimate the proportion of PH in neonatal sepsis using functional echocardiography (FnECHO). METHODS: This prospective observational study was conducted at a tertiary neonatal intensive care unit (NICU). All neonates admitted in the NICU with suspected LOS underwent FnECHO within 6 hours of onset of clinical signs and PASP was recorded. Pulmonary hypertension was defined as PASP of > 35 mmHg. PASP of neonates with positive culture results (proven LOS) was compared with that of gestational age-matched stable controls without sepsis. RESULTS: Thirty three neonates with proven LOS were analysed (study group). Sixteen neonates (49%) in the study group had PH. Mean PASP of the study group was significantly higher than that of the control group (35.3 ± 10.13 mmHg and 12.58 ± 3.92 mmHg, respectively; P < 0.0001). None of the neonates in the control group had PH. CONCLUSION: Pulmonary artery pressure was higher in neonates with late onset neonatal sepsis as compared to that of stable babies without sepsis. Pulmonary hypertension was seen in nearly half of term as well as preterm neonates with late onset sepsis.
Authors: Georg Hansmann; Christian Apitz; Hashim Abdul-Khaliq; Tero-Pekka Alastalo; Phillip Beerbaum; Damien Bonnet; Karl-Otto Dubowy; Matthias Gorenflo; Alfred Hager; Anne Hilgendorff; Michael Kaestner; Martin Koestenberger; Juha W Koskenvuo; Rainer Kozlik-Feldmann; Titus Kuehne; Astrid E Lammers; Heiner Latus; Ina Michel-Behnke; Oliver Miera; Shahin Moledina; Vivek Muthurangu; Joseph Pattathu; Dietmar Schranz; Gregor Warnecke; Peter Zartner Journal: Heart Date: 2016-05 Impact factor: 5.994
Authors: Martina A Steurer; Laura L Jelliffe-Pawlowski; Rebecca J Baer; J Colin Partridge; Elizabeth E Rogers; Roberta L Keller Journal: Pediatrics Date: 2016-12-01 Impact factor: 7.124