Georg Hansmann1, Christian Apitz2, Hashim Abdul-Khaliq3, Tero-Pekka Alastalo4, Phillip Beerbaum1, Damien Bonnet5, Karl-Otto Dubowy6, Matthias Gorenflo7, Alfred Hager8, Anne Hilgendorff9, Michael Kaestner2, Martin Koestenberger10, Juha W Koskenvuo4, Rainer Kozlik-Feldmann11, Titus Kuehne12, Astrid E Lammers13, Heiner Latus14, Ina Michel-Behnke15, Oliver Miera16, Shahin Moledina17, Vivek Muthurangu18, Joseph Pattathu7, Dietmar Schranz14, Gregor Warnecke19, Peter Zartner20. 1. Department of Paediatric Cardiology and Critical Care, Hannover Medical School, Hannover, Germany. 2. Division of Paediatric Cardiology, Children's University Hospital Ulm, Ulm, Germany. 3. Department of Paediatric Cardiology, Saarland University Hospital, Homburg, Germany. 4. Blueprint Genetics, Biomedicum Helsinki, Helsinki, Finland Department of Paediatric Cardiology, Children's Hospital Helsinki, University of Helsinki, Helsinki, Finland. 5. Unité Médico-Chirurgicale de Cardiologie Congénital et Pédiatrique, Centre de reference Malformations Cardiaques Congénitales Complexes-M3C, Hôpital Necker Enfants Malades, APHP, Université Paris Descartes, Sorbonne Paris, Paris, France. 6. Department of Paediatric Cardiology and Congenital Heart Disease, Heart and Diabetes Centre NRW, Bad Oeynhausen, Germany. 7. Department of Paediatric Cardiology, University of Heidelberg, Heidelberg, Germany. 8. Department of Paediatric Cardiology and Congenital Heart Disease, German Heart Centre Munich and Technical University, Munich, Germany. 9. Perinatal Center Grosshadern, Dr. von Haunersches Children's Hospital, Ludwig-Maximilians-University, Munich, Germany. 10. Divison of Paediatric Cardiology, Department of Paediatrics, Medical University Graz, Graz, Austria. 11. Division of Paediatric Cardiology, University Heart Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 12. German Heart Institute Berlin (DHZB), Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Paediatric Cardiology, Berlin, Germany. 13. Department of Paediatric Cardiology, University of Münster, Münster, Germany. 14. Justus-Liebig-University Giessen, Pediatric Cardiology, Paediatric Heart Center, Giessen, Germany. 15. Paediatric Heart Center, Division of Paediatric Cardiology, University Hospital for Children and Adolescents, Medical University Vienna, Austria. 16. German Heart Institute Berlin (DHZB), Department of Congenital Heart Disease and Paediatric Cardiology, Berlin, Germany. 17. National Paediatric Pulmonary Hypertension Service UK, Great Ormond Street Hospital for Children, London, UK. 18. Cardiovascular MRI Department, Great Ormond Street Hospital for Children, London, UK. 19. Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany German Centre for Lung Research, BREATH, Hannover, Germany. 20. Department of Paediatric Cardiology, German Paediatric Heart Centre, Sankt Augustin, Germany.
Abstract
UNLABELLED: : The European Paediatric Pulmonary Vascular Disease (PVD) Network is a registered, non-profit organisation that strives to define and develop effective, innovative diagnostic methods and treatment options in all forms of paediatric pulmonary hypertensive vascular disease, including specific forms such as pulmonary arterial hypertension (PAH)-congenital heart disease, pulmonary hypertension (PH) associated with bronchopulmonary dysplasia, persistent PH of the newborn, and related cardiac dysfunction. METHODS: The writing group members conducted searches of the PubMed/MEDLINE bibliographic database (1990-2015) and held five face-to-face meetings with votings. Clinical trials, guidelines, and reviews limited to paediatric data were searched using the terms 'pulmonary hypertensioń' and 5-10 other keywords, as outlined in the other nine articles of this special issue. Class of recommendation (COR) and level of evidence (LOE) were assigned based on European Society of Cardiology/American Heart Association definitions and on paediatric data only, or on adult studies that included >10% children. RESULTS: A total of 9 original consensus articles with graded recommendations (COR/LOE) were developed, and are summarised here. The topics included diagnosis/monitoring, genetics/biomarker, cardiac catheterisation, echocardiography, cardiac magnetic resonance/chest CT, associated forms of PH, intensive care unit/ventricular assist device/lung transplantation, and treatment of paediatric PAH. CONCLUSIONS: The multipaper expert consensus statement of the European Paediatric PVD Network provides a specific, comprehensive, detailed but practical framework for the optimal clinical care of children with PH. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
UNLABELLED: : The European Paediatric Pulmonary Vascular Disease (PVD) Network is a registered, non-profit organisation that strives to define and develop effective, innovative diagnostic methods and treatment options in all forms of paediatric pulmonary hypertensive vascular disease, including specific forms such as pulmonary arterial hypertension (PAH)-congenital heart disease, pulmonary hypertension (PH) associated with bronchopulmonary dysplasia, persistent PH of the newborn, and related cardiac dysfunction. METHODS: The writing group members conducted searches of the PubMed/MEDLINE bibliographic database (1990-2015) and held five face-to-face meetings with votings. Clinical trials, guidelines, and reviews limited to paediatric data were searched using the terms 'pulmonary hypertensioń' and 5-10 other keywords, as outlined in the other nine articles of this special issue. Class of recommendation (COR) and level of evidence (LOE) were assigned based on European Society of Cardiology/American Heart Association definitions and on paediatric data only, or on adult studies that included >10% children. RESULTS: A total of 9 original consensus articles with graded recommendations (COR/LOE) were developed, and are summarised here. The topics included diagnosis/monitoring, genetics/biomarker, cardiac catheterisation, echocardiography, cardiac magnetic resonance/chest CT, associated forms of PH, intensive care unit/ventricular assist device/lung transplantation, and treatment of paediatric PAH. CONCLUSIONS: The multipaper expert consensus statement of the European Paediatric PVD Network provides a specific, comprehensive, detailed but practical framework for the optimal clinical care of children with PH. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
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