Jaouad Yousfi1, Fatimazahra Bensalek1, Mouna Zahlane1, Laila Benjilali1, Lamiaa Essaadouni1.
Abstract
INTRODUCTION: Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction. PATIENT AND METHODS: We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma.
RESULTS: A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ≤0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin's lymphoma.
CONCLUSION: The association of lymphomas with myasthenia gravis has been rarely reported. LEARNING POINTS: Myasthenia gravis is an autoimmune disease of the neuromuscular junction and can be associated with malignant haemopathy.The coexistence of myasthenia and Hodgkin's lymphoma is very rare.This association is a therapeutic challenge. © EFIM 2021.
INTRODUCTION: Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction. PATIENT AND METHODS: We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma.
RESULTS: A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ≤0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin's lymphoma.
CONCLUSION: The association of lymphomas with myasthenia gravis has been rarely reported. LEARNING POINTS: Myasthenia gravis is an autoimmune disease of the neuromuscular junction and can be associated with malignant haemopathy.The coexistence of myasthenia and Hodgkin's lymphoma is very rare.This association is a therapeutic challenge. © EFIM 2021.
Entities:
Keywords:
Hodgkin’s lymphoma; Myasthenia gravis; paraneoplastic
Year: 2021
PMID： 33987113 PMCID： PMC8112101 DOI： 10.12890/2021_002375
Source DB: PubMed Journal: Eur J Case Rep Intern Med ISSN： 2284-2594