Literature DB >> 33983595

BRCA and Breast Cancer-Related High-Penetrance Genes.

Sang-Ah Han1, Sung-Won Kim2.   

Abstract

Genetic susceptibility explains 5-10% of all breast cancer cases. High-penetrance breast cancer susceptibility genes deliberate a greater than tenfold relative risk of breast cancer. BRCA1 and BRCA2 genes are the most common cause of hereditary breast cancer, and TP53, PTEN, and SKT11 (LKB1) are rarely present. The prevalence of BRCA1 and BRCA2 genetic alterations differ in various ethnic groups. The Korean Hereditary Breast Cancer (KOHBRA) Study, nationwide-scale study, was established to acquire evidence for the accurate risk assessment and management of hereditary breast and ovarian cancer (HBOC) in Korea prospectively since 2007. In this chapter, we review previous research related to hereditary breast cancer and summarize the present concepts and research results centered on the Korean Hereditary Breast Cancer Research at this time.

Entities:  

Keywords:  BRCA1/2; Breast cancer; Genetic susceptibility; KOHBRA study; PTEN; STK11; TP53

Mesh：

Year:  2021        PMID： 33983595     DOI： 10.1007/978-981-32-9620-6_25

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  49 in total

Review 1.  Inherited susceptibility to common cancers.

Authors:  William D Foulkes
Journal:  N Engl J Med       Date:  2008-11-13       Impact factor: 91.245

2.  Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.

Authors:  A Antoniou; P D P Pharoah; S Narod; H A Risch; J E Eyfjord; J L Hopper; N Loman; H Olsson; O Johannsson; A Borg; B Pasini; P Radice; S Manoukian; D M Eccles; N Tang; E Olah; H Anton-Culver; E Warner; J Lubinski; J Gronwald; B Gorski; H Tulinius; S Thorlacius; H Eerola; H Nevanlinna; K Syrjäkoski; O-P Kallioniemi; D Thompson; C Evans; J Peto; F Lalloo; D G Evans; D F Easton
Journal:  Am J Hum Genet       Date:  2003-04-03       Impact factor: 11.025

3.  BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives.

Authors:  Fiona Lalloo; Jennifer Varley; Anthony Moran; David Ellis; Lindsay O'dair; Paul Pharoah; Antonis Antoniou; Roger Hartley; Andrew Shenton; Sheila Seal; Barbara Bulman; Anthony Howell; D Gareth R Evans
Journal:  Eur J Cancer       Date:  2006-04-27       Impact factor: 9.162

4.  Identification of the breast cancer susceptibility gene BRCA2.

Authors:  R Wooster; G Bignell; J Lancaster; S Swift; S Seal; J Mangion; N Collins; S Gregory; C Gumbs; G Micklem
Journal:  Nature       Date:  1995 Dec 21-28       Impact factor: 49.962

Review 5.  Models of genetic susceptibility to breast cancer.

Authors:  A C Antoniou; D F Easton
Journal:  Oncogene       Date:  2006-09-25       Impact factor: 9.867

6.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Authors:  Y Miki; J Swensen; D Shattuck-Eidens; P A Futreal; K Harshman; S Tavtigian; Q Liu; C Cochran; L M Bennett; W Ding
Journal:  Science       Date:  1994-10-07       Impact factor: 47.728

7.  The genetic attributable risk of breast and ovarian cancer.

Authors:  E B Claus; J M Schildkraut; W D Thompson; N J Risch
Journal:  Cancer       Date:  1996-06-01       Impact factor: 6.860

Review 8.  PTEN hamartoma tumor syndrome: an overview.

Authors:  Judith A Hobert; Charis Eng
Journal:  Genet Med       Date:  2009-10       Impact factor: 8.822

9.  A genome wide linkage search for breast cancer susceptibility genes.

Authors:  Paula Smith; Lesley McGuffog; Douglas F Easton; Graham J Mann; Gulietta M Pupo; Beth Newman; Georgia Chenevix-Trench; Csilla Szabo; Melissa Southey; Hélène Renard; Fabrice Odefrey; Henry Lynch; Dominique Stoppa-Lyonnet; Fergus Couch; John L Hopper; Graham G Giles; Margaret R E McCredie; Saundra Buys; Irene Andrulis; Ruby Senie; David E Goldgar; Rogier Oldenburg; Karin Kroeze-Jansema; Jaennelle Kraan; Hanne Meijers-Heijboer; Jan G M Klijn; Christi van Asperen; Inge van Leeuwen; Hans F A Vasen; Cees J Cornelisse; Peter Devilee; Linda Baskcomb; Sheila Seal; Rita Barfoot; Jon Mangion; Anita Hall; Sarah Edkins; Elizabeth Rapley; Richard Wooster; Jenny Chang-Claude; Diana Eccles; D Gareth Evans; P Andrew Futreal; Katherine L Nathanson; Barbara L Weber; Nazneen Rahman; Michael R Stratton
Journal:  Genes Chromosomes Cancer       Date:  2006-07       Impact factor: 5.006

Review 10.  The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.

Authors:  K Gudmundsdottir; A Ashworth
Journal:  Oncogene       Date:  2006-09-25       Impact factor: 9.867
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