Literature DB >> 16998501

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.

K Gudmundsdottir1, A Ashworth.   

Abstract

The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 appears to involve regulating the function of RAD51 in the repair by homologous recombination. BRCA1 has a broader role upstream of BRCA2, participating in various cellular processes in response to DNA damage. The DNA repair defect associated with mutations in BRCA1 or BRCA2 could be exploited to develop new targeted therapeutic approaches for cancer occurring in mutation carriers.

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Year:  2006        PMID： 16998501     DOI： 10.1038/sj.onc.1209874

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


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