| Literature DB >> 33983581 |
Amos Chungwon Lee1,2, Han-Byoel Lee3,4,5, Huiran Yeom6, Seo Woo Song2, Su Deok Kim6, Ahyoun Choi1, Sumin Lee6, Yongju Lee6, Wonshik Han7,8,9, Sunghoon Kwon10,11,12,13.
Abstract
Intra- and Inter-tumoral heterogeneity is one of the main hurdles in diagnosing and treating breast cancer. Selecting, sampling, and sequencing the samples appropriately provide unique opportunities in realizing precision medicine. This chapter reviews some of the past landmarks, state-of-the-art technologies, and future directions of translational research in terms of tumor sampling technologies and sequencing in breast cancer. In the state-of-the-art technologies section, the technologies are categorized in terms of scientific, precision diagnostic, and precision therapeutic tools. Finally, limitations and future directions regarding various translational research for clinical applications using these technologies will be discussed.Entities:
Keywords: Circulating tumor DNA; Circulating tumor cells; Drug screening; Laser-induced cell sorting; Liquid biopsy; Single-cell sequencing; Spatially resolved sequencing; Tumor heterogeneity
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Year: 2021 PMID： 33983581 DOI： 10.1007/978-981-32-9620-6_11
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622