Literature DB >> 33972177

Multicolor fluorescence biosensors reveal a burning need for diversity in the single-cell metabolic landscape.

Md Torikul Islam1, William L Holland2, Lisa A Lesniewski3.   

Abstract

Although cellular heterogeneity has been described for metabolic pathways, the upstream mechanisms, the downstream consequences, and the flexibility and transmission of these preferences to daughter cells remains largely unknown. Using live-cell imaging, Kosaisawe et al. demonstrate that cellular metabolism, determined by glycolysis and ATP, is spontaneously heterogeneous, plastic, and regulatory.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  fluorescence biosensors; metabolic heterogeneity; single cell

Mesh：

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Year:  2021        PMID： 33972177      PMCID： PMC8381684          DOI： 10.1016/j.tem.2021.04.002

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   10.586


  10 in total

Review 1.  Cellular metabolism and disease: what do metabolic outliers teach us?

Authors:  Ralph J DeBerardinis; Craig B Thompson
Journal:  Cell       Date:  2012-03-16       Impact factor: 41.582

Review 2.  Mechanisms and Implications of Metabolic Heterogeneity in Cancer.

Authors:  Jiyeon Kim; Ralph J DeBerardinis
Journal:  Cell Metab       Date:  2019-09-03       Impact factor: 27.287

Review 3.  The spectrum of T cell metabolism in health and disease.

Authors:  Glenn R Bantug; Lorenzo Galluzzi; Guido Kroemer; Christoph Hess
Journal:  Nat Rev Immunol       Date:  2017-09-25       Impact factor: 53.106

4.  A fluorescent reporter of AMPK activity and cellular energy stress.

Authors:  Peiling Tsou; Bin Zheng; Chia-Hsien Hsu; Atsuo T Sasaki; Lewis C Cantley
Journal:  Cell Metab       Date:  2011-04-06       Impact factor: 27.287

5.  Deciphering Metabolic Heterogeneity by Single-Cell Analysis.

Authors:  Tom M J Evers; Mazène Hochane; Sander J Tans; Ron M A Heeren; Stefan Semrau; Peter Nemes; Alireza Mashaghi
Journal:  Anal Chem       Date:  2019-10-08       Impact factor: 6.986

6.  GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor.

Authors:  Hitomi Takanaga; Bhavna Chaudhuri; Wolf B Frommer
Journal:  Biochim Biophys Acta       Date:  2007-12-14

7.  Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Authors:  Laura Hulea; Simon-Pierre Gravel; Masahiro Morita; Marie Cargnello; Oro Uchenunu; Young Kyuen Im; Camille Lehuédé; Eric H Ma; Matthew Leibovitch; Shannon McLaughlan; Marie-José Blouin; Maxime Parisotto; Vasilios Papavasiliou; Cynthia Lavoie; Ola Larsson; Michael Ohh; Tiago Ferreira; Celia Greenwood; Gaëlle Bridon; Daina Avizonis; Gerardo Ferbeyre; Peter Siegel; Russell G Jones; William Muller; Josie Ursini-Siegel; Julie St-Pierre; Michael Pollak; Ivan Topisirovic
Journal:  Cell Metab       Date:  2018-09-20       Impact factor: 27.287

8.  Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.

Authors:  Yin P Hung; Carolyn Teragawa; Nont Kosaisawe; Taryn E Gillies; Michael Pargett; Marta Minguet; Kevin Distor; Briana L Rocha-Gregg; Jonathan L Coloff; Mark A Keibler; Gregory Stephanopoulos; Gary Yellen; Joan S Brugge; John G Albeck
Journal:  Elife       Date:  2017-12-14       Impact factor: 8.140

9.  Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms.

Authors:  Hiroshi Kondo; Colin D H Ratcliffe; Steven Hooper; James Ellis; James I MacRae; Marc Hennequart; Christopher W Dunsby; Kurt I Anderson; Erik Sahai
Journal:  Cell Rep       Date:  2021-02-16       Impact factor: 9.423

10.  Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells.

Authors:  Nont Kosaisawe; Breanne Sparta; Michael Pargett; Carolyn K Teragawa; John G Albeck
Journal:  Cell Metab       Date:  2021-02-08       Impact factor: 27.287
  10 in total

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