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Literature DB >> 3396862

HLA-sharing, recurrent spontaneous abortion, and the genetic hypothesis.

Abstract

A number of studies indicates that there is a high sharing of HLA antigens in couples having recurrent spontaneous abortions. The genetic hypothesis to explain this phenomenon suggests that this fetal loss results from homozygosity of recessive lethal or deleterious alleles in gametic disequilibrium with HLA antigens. Theory predicting the lethality rate is derived when antigens are shared at one, two or three loci, given that the disequilibrium is absolute. In addition, the effects of partial disequilibrium, inbreeding, and segregation distortion on the lethal proportion are examined.

Mesh：

Substances：
HLA Antigens

Year: 1988 PMID： 3396862 PMCID： PMC1203339

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

10 in total

1. The limits of ascertainment.

Authors: W J Ewens; N C Shute
Journal: Ann Hum Genet Date: 1986-10 Impact factor: 1.670

2. Maternal-fetal interactions and the maintenance of HLA polymorphism.

Authors: P W Hedrick; G Thomson
Journal: Genetics Date: 1988-05 Impact factor: 4.562

3. A comprehensive search for segregation distortion in HLA.

Authors: W Klitz; S K Lo; M Neugebauer; M P Baur; E D Albert; G Thomson
Journal: Hum Immunol Date: 1987-02 Impact factor: 2.850

4. The search for a human equivalent of the mouse T-locus - negative results from a study of HL-A types in spina bifida.

Authors: M Bobrow; J G Bodmer; W F Bodmer; H O McDevitt; J Lorber; P Swift
Journal: Tissue Antigens Date: 1975-05

5. Dynamics of correlated genetic systems. I. Selection in the region of the Glued locus of Drosophila melanogaster.

Authors: M T Clegg; J F Kidwell; M G Kidwell; N J Daniel
Journal: Genetics Date: 1976-08 Impact factor: 4.562

Review 6. Immunogenetics of spontaneous abortions in humans.

Authors: T J Gill
Journal: Transplantation Date: 1983-01 Impact factor: 4.939

7. Maternal-paternal histocompatibility: lack of association with habitual abortions.

Authors: J R Oksenberg; E Persitz; A Amar; C Brautbar
Journal: Fertil Steril Date: 1984-09 Impact factor: 7.329

8. Segregation of HLA A,B haplotypes and the distribution of antigen mismatches between mother and offspring in Hutterite families.

Authors: K Morgan; T M Holmes; F Pazderka; J B Dossetor
Journal: Am J Hum Genet Date: 1986-06 Impact factor: 11.025

9. HLA sharing and spontaneous abortion in humans.

Authors: M L Thomas; J H Harger; D K Wagener; B S Rabin; T J Gill
Journal: Am J Obstet Gynecol Date: 1985-04-15 Impact factor: 8.661

Review 10. Possible human analogs of the murine T/t complex.

Authors: C A Alper; Z L Awdeh; D D Raum; E J Yunis
Journal: Exp Clin Immunogenet Date: 1985

10 in total

5 in total

1. Influence of MHC and MHC-linked genes on reproduction.

Authors: T J Gill
Journal: Am J Hum Genet Date: 1992-01 Impact factor: 11.025

2. Major histocompatibility complex class II compatibility, but not class I, predicts mate choice in a bird with highly developed olfaction.

Authors: Maria Strandh; Helena Westerdahl; Mikael Pontarp; Björn Canbäck; Marie-Pierre Dubois; Christian Miquel; Pierre Taberlet; Francesco Bonadonna
Journal: Proc Biol Sci Date: 2012-09-05 Impact factor: 5.349