Literature DB >> 33966979

Bone marrow adipose tissue: Role in bone remodeling and energy metabolism.

Michaela Tencerova1, Michaela Ferencakova2, Moustapha Kassem3.   

Abstract

Bone marrow adipose tissue (BMAT) has been considered for several decades as a silent bystander that fills empty space left in bone marrow following age-related decrease in hematopoiesis. However, recently new discoveries revealed BMAT as a secretory and metabolically active organ contributing to bone and whole-body energy metabolism. BMAT exhibits metabolic functions distinct from extramedullary adipose depots, relevant to its role in regulation of energy metabolism and its contribution to fracture risk observed in metabolic bone diseases. This review discusses novel insights of BMAT with particular emphasis on its contribution to the regulation of bone homeostasis. We also discuss the role of BMAT in regulation of fuel utilization and energy use that affect skeletal stem cell functions.
Copyright © 2021. Published by Elsevier Ltd.

Entities:  

Keywords:  bone marrow adipose tissue; bone marrow mesenchymal stem cells; energy metabolism; metabolic pathways

Year:  2021        PMID： 33966979     DOI： 10.1016/j.beem.2021.101545

Source DB:  PubMed          Journal:  Best Pract Res Clin Endocrinol Metab        ISSN： 1521-690X            Impact factor:   4.690


  7 in total

Review 1.  Adipose tissue in bone regeneration - stem cell source and beyond.

Authors:  Luminita Labusca
Journal:  World J Stem Cells       Date:  2022-06-26       Impact factor: 5.247

Review 2.  Bone marrow adipose tissue in metabolic health.

Authors:  Gisela Pachón-Peña; Miriam A Bredella
Journal:  Trends Endocrinol Metab       Date:  2022-04-05       Impact factor: 10.586

3.  Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water-Fat MRI.

Authors:  Kerensa M Beekman; Martine Regenboog; Aart J Nederveen; Nathalie Bravenboer; Martin den Heijer; Peter H Bisschop; Carla E Hollak; Erik M Akkerman; Mario Maas
Journal:  Front Endocrinol (Lausanne)       Date:  2022-04-27       Impact factor: 6.055

4.  Bone marrow adipose tissue composition following high-caloric feeding and fasting.

Authors:  Miriam A Bredella; Colleen Buckless; Pouneh K Fazeli; Clifford J Rosen; Martin Torriani; Anne Klibanski; Karen K Miller
Journal:  Bone       Date:  2021-06-27       Impact factor: 4.398

Review 5.  Structural and Metabolic Changes in Bone.

Authors:  Agata Wawrzyniak; Krzysztof Balawender
Journal:  Animals (Basel)       Date:  2022-07-31       Impact factor: 3.231

6.  The extracellular matrix of human bone marrow adipocytes and glucose concentration differentially alter mineralization quality without impairing osteoblastogenesis.

Authors:  Laura Entz; Guillaume Falgayrac; Christophe Chauveau; Gilles Pasquier; Stéphanie Lucas
Journal:  Bone Rep       Date:  2022-09-20

Review 7.  Angiogenesis in adipose tissue and obesity.

Authors:  Silvia Corvera; Javier Solivan-Rivera; Zinger Yang Loureiro
Journal:  Angiogenesis       Date:  2022-07-20       Impact factor: 10.658
  7 in total

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