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Literature DB >> 35396163

Bone marrow adipose tissue in metabolic health.

Gisela Pachón-Peña¹, Miriam A Bredella².

Abstract

Recent studies have highlighted the role of bone marrow adipose tissue (BMAT) as a regulator of skeletal homeostasis and energy metabolism. While long considered an inert filler, occupying empty spaces from bone loss and reduced hematopoiesis, BMAT is now considered a secretory and metabolic organ that responds to nutritional challenges and secretes cytokines, which indirectly impact energy and bone metabolism. The recent advances in our understanding of the function of BMAT have been enabled by novel noninvasive imaging techniques, which allow longitudinal assessment of BMAT in vivo following interventions. This review will focus on the latest advances in our understanding of BMAT and its role in metabolic health. Imaging techniques to quantify the content and composition of BMAT will be discussed.

Entities: Chemical

Keywords: aging; bone marrow adipose tissue (BMAT); bone metabolism; caloric restriction; energy metabolism; proton magnetic resonance spectroscopy (1H-MRS)

Mesh：

Year: 2022 PMID： 35396163 PMCID： PMC9098665 DOI： 10.1016/j.tem.2022.03.003

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 10.586

Keyword Cloud
References

67 in total

1. Red and White Blood Cell Counts Are Associated With Bone Marrow Adipose Tissue, Bone Mineral Density, and Bone Microarchitecture in Premenopausal Women.

Authors: Sai Polineni; Megi Resulaj; Alexander T Faje; Erinne Meenaghan; Miriam A Bredella; Mary Bouxsein; Hang Lee; Ormond A MacDougald; Anne Klibanski; Pouneh K Fazeli
Journal: J Bone Miner Res Date: 2020-03-23 Impact factor: 6.741

Review 2. Clinical imaging of marrow adiposity.

Authors: Mohamed Jarraya; Miriam A Bredella
Journal: Best Pract Res Clin Endocrinol Metab Date: 2021-02-20 Impact factor: 4.690

3. Effects of growth hormone administration for 6 months on bone turnover and bone marrow fat in obese premenopausal women.

Authors: Miriam A Bredella; Anu V Gerweck; Lauren A Barber; Anne Breggia; Clifford J Rosen; Martin Torriani; Karen K Miller
Journal: Bone Date: 2014-02-05 Impact factor: 4.398

4. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

Authors: Wendy W Pang; Elizabeth A Price; Debashis Sahoo; Isabel Beerman; William J Maloney; Derrick J Rossi; Stanley L Schrier; Irving L Weissman
Journal: Proc Natl Acad Sci U S A Date: 2011-11-28 Impact factor: 11.205

5. Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass.

Authors: Tiffany Y Kim; Ann V Schwartz; Xiaojuan Li; Kaipin Xu; Dennis M Black; Dimitry M Petrenko; Lygia Stewart; Stanley J Rogers; Andrew M Posselt; Jonathan T Carter; Dolores M Shoback; Anne L Schafer
Journal: J Bone Miner Res Date: 2017-08-09 Impact factor: 6.741

6. Marrow adiposity assessed on transiliac crest biopsy samples correlates with noninvasive measurement of marrow adiposity by proton magnetic resonance spectroscopy ((1)H-MRS) at the spine but not the femur.

Authors: A Cohen; W Shen; D W Dempster; H Zhou; R R Recker; J M Lappe; A Kepley; M Kamanda-Kosseh; M Bucovsky; E M Stein; T L Nickolas; E Shane
Journal: Osteoporos Int Date: 2015-05-19 Impact factor: 4.507

Bone marrow adipose tissue in metabolic health.

1. Red and White Blood Cell Counts Are Associated With Bone Marrow Adipose Tissue, Bone Mineral Density, and Bone Microarchitecture in Premenopausal Women.

Review 2. Clinical imaging of marrow adiposity.

3. Effects of growth hormone administration for 6 months on bone turnover and bone marrow fat in obese premenopausal women.

4. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

5. Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass.

6. Marrow adiposity assessed on transiliac crest biopsy samples correlates with noninvasive measurement of marrow adiposity by proton magnetic resonance spectroscopy ((1)H-MRS) at the spine but not the femur.

7. Short-term caloric restriction induced bone loss in both axial and appendicular bones by increasing adiponectin.

Review 8. Bone Marrow Adipocytes-Role in Physiology and Various Nutritional Conditions in Human and Animal Models.

9. A critical relationship between bone and fat: the role of bone marrow adipose-derived RANKL in bone metabolism.

10. Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation.