Milica Medved1,2, Aritrick Chatterjee1,2, Ajit Devaraj3, Carla Harmath1, Grace Lee1, Ambereen Yousuf1,2, Tatjana Antic4, Aytekin Oto1,2, Gregory S Karczmar1,2. 1. Department of Radiology, University of Chicago, Chicago, Illinois, USA. 2. Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy, University of Chicago, Chicago, Illinois, USA. 3. Philips Research NA, Cambridge, Massachusetts, USA. 4. Department of Pathology, University of Chicago, Chicago, Illinois, USA.
Abstract
PURPOSE: High spectral and spatial resolution (HiSS) MRI is a spectroscopic imaging method focusing on water and fat resonances that has good diagnostic utility in breast imaging. The purpose of this work was to assess the feasibility and potential utility of HiSS MRI for the diagnosis of prostate cancer. METHODS: HiSS MRI was acquired at 3 T from six patients who underwent prostatectomy, yielding a train of 127 phase-coherent gradient echo (GRE) images. In the temporal domain, changes in voxel intensity were analyzed and linear (R) and quadratic (R1, R2) quantifiers of signal logarithm decay were calculated. In the spectral domain, three signal scaling-independent parameters were calculated: water resonance peak width (PW), relative peak asymmetry (PRA), and relative peak distortion from ideal Lorentzian shape (PRD). Seven cancer and five normal tissue regions of interest were identified in correlation with pathology and compared. RESULTS: HiSS-derived quantifiers, except R2, showed high reproducibility (coefficients of variation, 5%-14%). Spectral domain quantifiers performed better than temporal domain quantifiers, with receiver operator characteristic areas under the curve ranging from of 0.83 to 0.91. For temporal domain parameters, the range was 0.74 to 0.91. Low absolute values of the coefficients of correlation between monoexponential decay markers (R, PW) and resonance shape markers (PRA, PRD) were observed (range, 0.23-0.38). CONCLUSION: The feasibility and potential diagnostic utility of HiSS MRI in the prostate at 3 T without an endorectal coil was confirmed. Weak correlation between well-performing markers indicates that complementary information could be leveraged to further improve diagnostic accuracy.
PURPOSE: High spectral and spatial resolution (HiSS) MRI is a spectroscopic imaging method focusing on water and fat resonances that has good diagnostic utility in breast imaging. The purpose of this work was to assess the feasibility and potential utility of HiSS MRI for the diagnosis of prostate cancer. METHODS: HiSS MRI was acquired at 3 T from six patients who underwent prostatectomy, yielding a train of 127 phase-coherent gradient echo (GRE) images. In the temporal domain, changes in voxel intensity were analyzed and linear (R) and quadratic (R1, R2) quantifiers of signal logarithm decay were calculated. In the spectral domain, three signal scaling-independent parameters were calculated: water resonance peak width (PW), relative peak asymmetry (PRA), and relative peak distortion from ideal Lorentzian shape (PRD). Seven cancer and five normal tissue regions of interest were identified in correlation with pathology and compared. RESULTS: HiSS-derived quantifiers, except R2, showed high reproducibility (coefficients of variation, 5%-14%). Spectral domain quantifiers performed better than temporal domain quantifiers, with receiver operator characteristic areas under the curve ranging from of 0.83 to 0.91. For temporal domain parameters, the range was 0.74 to 0.91. Low absolute values of the coefficients of correlation between monoexponential decay markers (R, PW) and resonance shape markers (PRA, PRD) were observed (range, 0.23-0.38). CONCLUSION: The feasibility and potential diagnostic utility of HiSS MRI in the prostate at 3 T without an endorectal coil was confirmed. Weak correlation between well-performing markers indicates that complementary information could be leveraged to further improve diagnostic accuracy.
Authors: Milica Medved; Xiaobing Fan; Hiroyuki Abe; Gillian M Newstead; Abbie M Wood; Akiko Shimauchi; Kirti Kulkarni; Marko K Ivancevic; Lorenzo L Pesce; Olufunmilayo I Olopade; Gregory S Karczmar Journal: Acad Radiol Date: 2011-10-01 Impact factor: 3.173
Authors: Milica Medved; Marko K Ivancevic; Olufunmilayo I Olopade; Gillian M Newstead; Gregory S Karczmar Journal: Magn Reson Med Date: 2010-06 Impact factor: 4.668
Authors: Deanna L Langer; Theodorus H van der Kwast; Andrew J Evans; Anna Plotkin; John Trachtenberg; Brian C Wilson; Masoom A Haider Journal: Radiology Date: 2010-05 Impact factor: 11.105
Authors: Milica Medved; Weiliang Du; Marta A Zamora; Xiaobing Fan; Olufunmilayo I Olopade; Peter M MacEneaney; Gillian Newstead; Gregory S Karczmar Journal: J Magn Reson Imaging Date: 2003-10 Impact factor: 4.813
Authors: Baris Turkbey; Andrew B Rosenkrantz; Masoom A Haider; Anwar R Padhani; Geert Villeirs; Katarzyna J Macura; Clare M Tempany; Peter L Choyke; Francois Cornud; Daniel J Margolis; Harriet C Thoeny; Sadhna Verma; Jelle Barentsz; Jeffrey C Weinreb Journal: Eur Urol Date: 2019-03-18 Impact factor: 20.096
Authors: Hashim U Ahmed; Ahmed El-Shater Bosaily; Louise C Brown; Rhian Gabe; Richard Kaplan; Mahesh K Parmar; Yolanda Collaco-Moraes; Katie Ward; Richard G Hindley; Alex Freeman; Alex P Kirkham; Robert Oldroyd; Chris Parker; Mark Emberton Journal: Lancet Date: 2017-01-20 Impact factor: 79.321