Akos Varga-Szemes1, Pascale Aouad2, U Joseph Schoepf3, Tilman Emrich3,4,5, Basel Yacoub3, Thomas M Todoran6, Ioannis Koktzoglou7,8, Robert R Edelman2,7. 1. Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. vargaasz@musc.edu. 2. Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. 3. Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA. 4. Department of Diagnostic and Interventional Radiology, University Medical Center, Mainz, Germany. 5. German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany. 6. Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA. 7. Department of Radiology, Northshore University HealthSystem, Evanston, IL, USA. 8. University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Abstract
OBJECTIVE: To evaluate the potential clinical benefit of the superior spatial resolution of 3D prototype thin-slab stack-of-stars (tsSOS) quiescent-interval slice-selective (QISS) MRA over standard 2D-QISS MRA for the detection peripheral artery disease (PAD), using computed tomography angiography (CTA) as reference. MATERIALS AND METHODS: Twenty-three patients (70 ± 8 years, 18 men) with PAD who had previously undergone run-off CTA were prospectively enrolled. Patients underwent non-contrast MRA using 2D-QISS and tsSOS-QISS at 1.5 T. Eighteen arterial segments were evaluated for subjective and objective image quality (normalized signal-to-noise, nSNR), vessel sharpness, and area under the curve (AUC) for > 50% stenosis detection. RESULTS: Overall subjective image quality ratings for the entire run-off were not different between tsSOS-QISS and 2D-QISS (3 [3; 4] vs 4 [3; 4], respectively; P = 0.813). Sharpness of primary branch vessels demonstrated improved image quality using tsSOS-QISS compared with 2D-QISS (4 [3; 4] vs 3 [2; 3], P = 0.008). Objective image quality measures were not different between 2D-QISS and tsSOS-QISS (nSNR 5.0 ± 1.9 vs 4.2 ± 1.8; P = 0.132). AUCs for significant stenosis detection by tsSOS-QISS and 2D-QISS were 0.877 and 0.856, respectively (P = 0.336). DISCUSSION: The prototype 3D tsSOS-QISS technique provides similar accuracy in patients with PAD to a standard commercially available 2D-QISS technique, indicating that the use of relatively thick slices does not limit the diagnostic performance of 2D-QISS. However, subjective image quality for branch vessel depiction is improved using the 3D approach.
OBJECTIVE: To evaluate the potential clinical benefit of the superior spatial resolution of 3D prototype thin-slab stack-of-stars (tsSOS) quiescent-interval slice-selective (QISS) MRA over standard 2D-QISS MRA for the detection peripheral artery disease (PAD), using computed tomography angiography (CTA) as reference. MATERIALS AND METHODS: Twenty-three patients (70 ± 8 years, 18 men) with PAD who had previously undergone run-off CTA were prospectively enrolled. Patients underwent non-contrast MRA using 2D-QISS and tsSOS-QISS at 1.5 T. Eighteen arterial segments were evaluated for subjective and objective image quality (normalized signal-to-noise, nSNR), vessel sharpness, and area under the curve (AUC) for > 50% stenosis detection. RESULTS: Overall subjective image quality ratings for the entire run-off were not different between tsSOS-QISS and 2D-QISS (3 [3; 4] vs 4 [3; 4], respectively; P = 0.813). Sharpness of primary branch vessels demonstrated improved image quality using tsSOS-QISS compared with 2D-QISS (4 [3; 4] vs 3 [2; 3], P = 0.008). Objective image quality measures were not different between 2D-QISS and tsSOS-QISS (nSNR 5.0 ± 1.9 vs 4.2 ± 1.8; P = 0.132). AUCs for significant stenosis detection by tsSOS-QISS and 2D-QISS were 0.877 and 0.856, respectively (P = 0.336). DISCUSSION: The prototype 3D tsSOS-QISS technique provides similar accuracy in patients with PAD to a standard commercially available 2D-QISS technique, indicating that the use of relatively thick slices does not limit the diagnostic performance of 2D-QISS. However, subjective image quality for branch vessel depiction is improved using the 3D approach.
Entities:
Keywords:
Computed tomography angiography; Magnetic resonance angiography; Peripheral arterial disease
Authors: L Norgren; W R Hiatt; J A Dormandy; M R Nehler; K A Harris; F G R Fowkes; R B Rutherford Journal: Int Angiol Date: 2007-06 Impact factor: 2.789
Authors: Akos Varga-Szemes; Megha Penmetsa; Tilman Emrich; Thomas M Todoran; Pal Suranyi; Stephen R Fuller; Robert R Edelman; Ioannis Koktzoglou; U Joseph Schoepf Journal: Eur Radiol Date: 2020-10-17 Impact factor: 5.315