Literature DB >> 33963191

A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice.

Jovin J Y Choo1, Laura J Vet1, Christopher L D McMillan1, Jessica J Harrison1, Connor A P Scott1, Alexandra C I Depelsenaire2, Germain J P Fernando1,2, Daniel Watterson1, Roy A Hall1, Paul R Young1, Jody Hobson-Peters3, David A Muller4.   

Abstract

Dengue viruses (DENV) cause an estimated 390 million infections globally. With no dengue-specific therapeutic treatment currently available, vaccination is the most promising strategy for its control. A wide range of DENV vaccines are in development, with one having already been licensed, albeit with limited distribution. We investigated the immunogenicity and protective efficacy of a chimeric virus vaccine candidate based on the insect-specific flavivirus, Binjari virus (BinJV), displaying the structural prM/E proteins of DENV (BinJ/DENV2-prME). In this study, we immunized AG129 mice with BinJ/DENV2-prME via a needle-free, high-density microarray patch (HD-MAP) delivery system. Immunization with a single, 1 µg dose of BinJ/DENV2-prME delivered via the HD-MAPs resulted in enhanced kinetics of neutralizing antibody induction when compared to needle delivery and complete protection against mortality upon virus challenge in the AG129 DENV mouse model.

Entities:  

Year:  2021        PMID： 33963191     DOI： 10.1038/s41541-021-00328-1

Source DB:  PubMed          Journal:  NPJ Vaccines        ISSN： 2059-0105            Impact factor:   7.344


  42 in total

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6.  Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial.

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Journal:  Lancet       Date:  2014-07-10       Impact factor: 79.321

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10.  Association of Microvascular Function and Endothelial Biomarkers With Clinical Outcome in Dengue: An Observational Study.

Authors:  Sophie Yacoub; Phung Khanh Lam; Le Hoang Mai Vu; Thi Lien Le; Ngo Thanh Ha; Tran Thi Toan; Nguyen Thu Van; Nguyen Than Ha Quyen; Huynh Thi Le Duyen; Nguyen Van Kinh; Annette Fox; Juthathip Mongkolspaya; Marcel Wolbers; Cameron Paul Simmons; Gavin Robert Screaton; Heiman Wertheim; Bridget Wills
Journal:  J Infect Dis       Date:  2016-05-26       Impact factor: 5.226
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  8 in total

1.  Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern.

Authors:  Christopher L D McMillan; Alberto A Amarilla; Naphak Modhiran; Jovin J Y Choo; Armira Azuar; Kate E Honeyman; Alexander A Khromykh; Paul R Young; Daniel Watterson; David A Muller
Journal:  Vaccine       Date:  2022-07-18       Impact factor: 4.169

2.  Dermal Delivery of a SARS-CoV-2 Subunit Vaccine Induces Immunogenicity against Variants of Concern.

Authors:  Christopher L D McMillan; Armira Azuar; Jovin J Y Choo; Naphak Modhiran; Alberto A Amarilla; Ariel Isaacs; Kate E Honeyman; Stacey T M Cheung; Benjamin Liang; Maria J Wurm; Paco Pino; Joeri Kint; Germain J P Fernando; Michael J Landsberg; Alexander A Khromykh; Jody Hobson-Peters; Daniel Watterson; Paul R Young; David A Muller
Journal:  Vaccines (Basel)       Date:  2022-04-08

3.  Complete protection by a single-dose skin patch-delivered SARS-CoV-2 spike vaccine.

Authors:  Christopher L D McMillan; Jovin J Y Choo; Adi Idris; Aroon Supramaniam; Naphak Modhiran; Alberto A Amarilla; Ariel Isaacs; Stacey T M Cheung; Benjamin Liang; Helle Bielefeldt-Ohmann; Armira Azuar; Dhruba Acharya; Gabrielle Kelly; Germain J P Fernando; Michael J Landsberg; Alexander A Khromykh; Daniel Watterson; Paul R Young; Nigel A J McMillan; David A Muller
Journal:  Sci Adv       Date:  2021-10-29       Impact factor: 14.136

4.  Local Response and Barrier Recovery in Elderly Skin Following the Application of High-Density Microarray Patches.

Authors:  Fredrik Iredahl; David A Muller; Totte Togö; Hanna Jonasson; Ben Baker; Chris D Anderson; Joakim Henricson
Journal:  Vaccines (Basel)       Date:  2022-04-10

Review 5.  Engineering carbon nanotubes for sensitive viral detection.

Authors:  Muhammad Ovais; Min You; Jalal Ahmad; Ridha Djellabi; Arbab Ali; Mahmood Hassan Akhtar; Manzar Abbas; Chunying Chen
Journal:  Trends Analyt Chem       Date:  2022-04-30       Impact factor: 14.908

6.  Reporter Flaviviruses as Tools to Demonstrate Homologous and Heterologous Superinfection Exclusion.

Authors:  Francisco J Torres; Rhys Parry; Leon E Hugo; Andrii Slonchak; Natalee D Newton; Laura J Vet; Naphak Modhiran; Brody Pullinger; Xiaohui Wang; James Potter; Clay Winterford; Jody Hobson-Peters; Roy A Hall; Alexander A Khromykh
Journal:  Viruses       Date:  2022-07-08       Impact factor: 5.818

7.  The Chimeric Binjari-Zika Vaccine Provides Long-Term Protection against ZIKA Virus Challenge.

Authors:  Jessamine E Hazlewood; Bing Tang; Kexin Yan; Daniel J Rawle; Jessica J Harrison; Roy A Hall; Jody Hobson-Peters; Andreas Suhrbier
Journal:  Vaccines (Basel)       Date:  2022-01-06

8.  Implications of Dengue Virus Maturation on Vaccine Induced Humoral Immunity in Mice.

Authors:  Connor A P Scott; Alberto A Amarilla; Summa Bibby; Natalee D Newton; Roy A Hall; Jody Hobson-Peters; David A Muller; Keith J Chappell; Paul R Young; Naphak Modhiran; Daniel Watterson
Journal:  Viruses       Date:  2021-09-15       Impact factor: 5.048
  8 in total

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