| Literature DB >> 15057297 |
Abstract
Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.Entities:
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Year: 2004 PMID: 15057297 PMCID: PMC379334 DOI: 10.1172/JCI21512
Source DB: PubMed Journal: J Clin Invest ISSN: 0021-9738 Impact factor: 14.808