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Literature DB >> 33956024

Amino acid-based H₂S donors: N-thiocarboxyanhydrides that release H₂S with innocuous byproducts.

Kuljeet Kaur¹, Patrick Enders², Yumeng Zhu³, Abigail F Bratton³, Chadwick R Powell³, Khosrow Kashfi⁴, John B Matson³.

Abstract

A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.

Entities: Chemical

Mesh：

Substances：

Year: 2021 PMID： 33956024 PMCID： PMC8178226 DOI： 10.1039/d1cc01309b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.065

32 in total

1. Gasotransmitters: growing pains and joys.

Authors: Rui Wang
Journal: Trends Biochem Sci Date: 2014-04-22 Impact factor: 13.807

2. Insights into the Mechanism of Thiol-Triggered COS/H₂S Release from N-Dithiasuccinoyl Amines.

Authors: Shengchao Zhou; Yujie Mou; Miao Liu; Qian Du; Basharat Ali; Jurupula Ramprasad; Chunhua Qiao; Li-Fang Hu; Xingyue Ji
Journal: J Org Chem Date: 2020-06-17 Impact factor: 4.354

Review 3. The Benefits of Macromolecular/Supramolecular Approaches in Hydrogen Sulfide Delivery: A Review of Polymeric and Self-Assembled Hydrogen Sulfide Donors.

Authors: Kuljeet Kaur; Ryan J Carrazzone; John B Matson
Journal: Antioxid Redox Signal Date: 2020-01-10 Impact factor: 8.401

Review 4. Toward Hydrogen Sulfide Based Therapeutics: Critical Drug Delivery and Developability Issues.

Authors: Yueqin Zheng; Bingchen Yu; Ladie Kimberly De La Cruz; Manjusha Roy Choudhury; Abiodun Anifowose; Binghe Wang
Journal: Med Res Rev Date: 2017-02-27 Impact factor: 12.944

5. Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H₂S) Donors.

Authors: Preeti Chauhan; Prerona Bora; Govindan Ravikumar; Swetha Jos; Harinath Chakrapani
Journal: Org Lett Date: 2016-12-20 Impact factor: 6.005

Review 6. H2S-releasing drugs: anti-inflammatory, cytoprotective and chemopreventative potential.

Authors: Burcu Gemici; Wagdi Elsheikh; Karla B Feitosa; Soraia K P Costa; Marcelo N Muscara; John L Wallace
Journal: Nitric Oxide Date: 2014-11-18 Impact factor: 4.427

Review 7. The dichotomous role of H₂S in cancer cell biology? Déjà vu all over again.

Authors: Khosrow Kashfi
Journal: Biochem Pharmacol Date: 2018-02-14 Impact factor: 5.858

Review 8. The metabolism and toxicity of quinones, quinonimines, quinone methides, and quinone-thioethers.

Authors: Terrence J Monks; Douglas C Jones
Journal: Curr Drug Metab Date: 2002-08 Impact factor: 3.731

9. Use of Dithiasuccinoyl-Caged Amines Enables COS/H₂ S Release Lacking Electrophilic Byproducts.

Authors: Matthew M Cerda; Jenna L Mancuso; Emma J Mullen; Christopher H Hendon; Michael D Pluth
Journal: Chemistry Date: 2020-03-04 Impact factor: 5.236

10. Hydrogen Sulfide Therapy in Diabetes-Accelerated Atherosclerosis: A Whiff of Success.

Authors: William Durante
Journal: Diabetes Date: 2016-10 Impact factor: 9.461

2 in total

1. Electrospun Scaffolds Functionalized with a Hydrogen Sulfide Donor Stimulate Angiogenesis.

Authors: Tianyu Yao; Teun van Nunen; Rebeca Rivero; Chadwick Powell; Ryan Carrazzone; Lilian Kessels; Paul Andrew Wieringa; Shahzad Hafeez; Tim G A M Wolfs; Lorenzo Moroni; John B Matson; Matthew B Baker
Journal: ACS Appl Mater Interfaces Date: 2022-06-17 Impact factor: 10.383

Review 2. Moving Past Quinone-Methides: Recent Advances Toward Minimizing Electrophilic Byproducts from COS/H₂S Donors.

Authors: Michael D Pluth
Journal: Curr Top Med Chem Date: 2021 Impact factor: 3.570