Literature DB >> 27996277

Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors.

Preeti Chauhan1, Prerona Bora1, Govindan Ravikumar1, Swetha Jos1, Harinath Chakrapani1.   

Abstract

Hydrogen sulfide (H2S) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of H2S is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to H2S.

Entities:  

Year:  2016        PMID： 27996277     DOI： 10.1021/acs.orglett.6b03336

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  32 in total

1.  H2S donors with optical responses.

Authors:  Michael D Pluth; Yu Zhao; Matthew M Cerda
Journal:  Methods Enzymol       Date:  2020-06-15       Impact factor: 1.600

2.  Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H2S Donors.

Authors:  Andrea K Steiger; Michela Marcatti; Csaba Szabo; Bartosz Szczesny; Michael D Pluth
Journal:  ACS Chem Biol       Date:  2017-06-30       Impact factor: 5.100

3.  Self-Immolative Prodrugs: Effective Tools for the Controlled Release of Sulfur Signaling Species.

Authors:  Kearsley M Dillon; Chadwick R Powell; John B Matson
Journal:  Synlett       Date:  2019-01-09       Impact factor: 2.454

4.  Characterization and Biological Activity of a Hydrogen Sulfide-Releasing Red Light-Activated Ruthenium(II) Complex.

Authors:  Joshua J Woods; Jian Cao; Alexander R Lippert; Justin J Wilson
Journal:  J Am Chem Soc       Date:  2018-09-19       Impact factor: 15.419

Review 5.  Emerging Roles of Carbonyl Sulfide in Chemical Biology: Sulfide Transporter or Gasotransmitter?

Authors:  Andrea K Steiger; Yu Zhao; Michael D Pluth
Journal:  Antioxid Redox Signal       Date:  2017-05-18       Impact factor: 8.401

6.  Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Authors:  Roy Weinstain; Tomáš Slanina; Dnyaneshwar Kand; Petr Klán
Journal:  Chem Rev       Date:  2020-10-30       Impact factor: 60.622

7.  Supramolecular nanostructures with tunable donor loading for controlled H2S release.

Authors:  Yin Wang; John B Matson
Journal:  ACS Appl Bio Mater       Date:  2019-10-16

8.  Development of Acid-Mediated H2S/COS Donors That Respond to a Specific pH Window.

Authors:  Annie K Gilbert; Yu Zhao; Claire E Otteson; Michael D Pluth
Journal:  J Org Chem       Date:  2019-09-18       Impact factor: 4.354

9.  Cyclic Sulfenyl Thiocarbamates Release Carbonyl Sulfide and Hydrogen Sulfide Independently in Thiol-Promoted Pathways.

Authors:  Yu Zhao; Andrea K Steiger; Michael D Pluth
Journal:  J Am Chem Soc       Date:  2019-08-14       Impact factor: 15.419

10.  Polymeric persulfide prodrugs: Mitigating oxidative stress through controlled delivery of reactive sulfur species.

Authors:  Kearsley M Dillon; Ryan J Carrazzone; Yin Wang; Chadwick R Powell; John B Matson
Journal:  ACS Macro Lett       Date:  2020-04-07       Impact factor: 6.903
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