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Literature DB >> 33947142

lncRNA PVT1 in the Pathogenesis and Clinical Management of Renal Cell Carcinoma.

Julia Bohosova¹, Adela Kubickova², Ondrej Slaby^1,3.

Abstract

LncRNA PVT1 (plasmacytoma variant translocation 1) has become a staple of the lncRNA profile in patients with renal cell carcinoma (RCC). Common dysregulation in renal tumors outlines the essential role of PVT1 in the development of RCC. There is already a plethora of publications trying to uncover the cellular mechanisms of PVT1-mediated regulation and its potential exploitation in management of RCC. In this review, we summarize the literature focused on PVT1 in RCC and aim to synthesize the current knowledge on its role in the cells of the kidney. Further, we provide an overview of the lncRNA profiling studies that have identified a more or less significant association of PVT1 with the clinical behavior of RCC. Based on our search, we analyzed the 17 scientific papers discussed in this review that provide robust support for the indispensable role of PVT1 in RCC development and future personalized therapy.

Entities: Chemical Disease Gene Species

Keywords: biomarker; diagnosis; long non-coding RNA; prognosis; tumorigenesis

Year: 2021 PMID： 33947142 DOI： 10.3390/biom11050664

Source DB: PubMed Journal: Biomolecules ISSN： 2218-273X

108 in total

1. Jpx RNA activates Xist by evicting CTCF.

Authors: Sha Sun; Brian C Del Rosario; Attila Szanto; Yuya Ogawa; Yesu Jeon; Jeannie T Lee
Journal: Cell Date: 2013-06-20 Impact factor: 41.582

2. Upregulation of long noncoding RNA PVT1 predicts unfavorable prognosis in patients with clear cell renal cell carcinoma.

Authors: Xu Bao; Junyao Duan; Yongji Yan; Xin Ma; Yu Zhang; Hanfeng Wang; Dong Ni; Shengpan Wu; Cheng Peng; Yang Fan; Yu Gao; Xintao Li; Jianwen Chen; Qingshan Du; Fan Zhang; Xu Zhang
Journal: Cancer Biomark Date: 2017-12-12 Impact factor: 4.388

Review 3. Molecular mechanisms of long noncoding RNAs.

Authors: Kevin C Wang; Howard Y Chang
Journal: Mol Cell Date: 2011-09-16 Impact factor: 17.970

4. Identification of protein-coding and intronic noncoding RNAs down-regulated in clear cell renal carcinoma.

Authors: Glauber Costa Brito; Angela A Fachel; Andre Luiz Vettore; Giselle M Vignal; Etel R P Gimba; Franz S Campos; Marcello A Barcinski; Sergio Verjovski-Almeida; Eduardo M Reis
Journal: Mol Carcinog Date: 2008-10 Impact factor: 4.784

5. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.

Authors: Mohammad Ali Faghihi; Farzaneh Modarresi; Ahmad M Khalil; Douglas E Wood; Barbara G Sahagan; Todd E Morgan; Caleb E Finch; Georges St Laurent; Paul J Kenny; Claes Wahlestedt
Journal: Nat Med Date: 2008-06-29 Impact factor: 53.440

Review 6. Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression.

Authors: Qinyu Sun; Qinyu Hao; Kannanganattu V Prasanth
Journal: Trends Genet Date: 2018-02-07 Impact factor: 11.639

7. Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

Authors: Johannes Schödel; Chiara Bardella; Lina K Sciesielski; Jill M Brown; Chris W Pugh; Veronica Buckle; Ian P Tomlinson; Peter J Ratcliffe; David R Mole
Journal: Nat Genet Date: 2012-03-11 Impact factor: 38.330

8. A serum-circulating long noncoding RNA signature can discriminate between patients with clear cell renal cell carcinoma and healthy controls.

Authors: Y Wu; Y-Q Wang; W-W Weng; Q-Y Zhang; X-Q Yang; H-L Gan; Y-S Yang; P-P Zhang; M-H Sun; M-D Xu; C-F Wang
Journal: Oncogenesis Date: 2016-02-15 Impact factor: 7.485

9. Long Non-Coding RNA Plasmacytoma Variant Translocation 1 (PVT1) Enhances Proliferation, Migration, and Epithelial-Mesenchymal Transition (EMT) of Pituitary Adenoma Cells by Activating β-Catenin, c-Myc, and Cyclin D1 Expression.

Authors: Yihua Zhang; Yang Tan; Hao Wang; Minhui Xu; Lunshan Xu
Journal: Med Sci Monit Date: 2019-10-12

10. lncRNA PVT1 and its splicing variant function as competing endogenous RNA to regulate clear cell renal cell carcinoma progression.

Authors: Tao Yang; Hui Zhou; Peijun Liu; Libin Yan; Weimin Yao; Ke Chen; Jin Zeng; Heng Li; Junhui Hu; Hua Xu; Zhangqun Ye
Journal: Oncotarget Date: 2017-07-31

4 in total

1. A Prognostic Signature for Clear Cell Renal Cell Carcinoma Based on Ferroptosis-Related lncRNAs and Immune Checkpoints.

Authors: Yunze Dong; Ding Liu; Hongmin Zhou; Yuchen Gao; Yimingniyizi Nueraihemaiti; Yunfei Xu
Journal: Front Genet Date: 2022-05-24 Impact factor: 4.772