Rui She1, Zhongrui Yan2, Yanlei Hao3, Zuoji Zhang4, Yifeng Du5, Yajun Liang6,7, Davide L Vetrano7,8, Joost Dekker9, Bo Bai4, Joseph T F Lau10, Chengxuan Qiu11,12. 1. JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China. 2. Department of Neurology, Jining No. 1 People's Hospital, Jining, Shandong, China. 3. The Affiliated Hospital of Jining Medical University, Jining, Shandong, China. 4. Jining Medical University, Jining, Shandong, China. 5. Department of Neurology, Shandong Provincial Hospital Affiliated To Shandong University, Jinan, Shandong, China. 6. Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. 7. Care Sciences and Society, Department of Neurobiology, Aging Research Center, Karolinska Institutet-Stockholm University, Tomtebodavägen 18A, 171 65, Stockholm, Solna, Sweden. 8. Centro Medicina dell'Invecchiamento IRCCS Fondazione Policlinico "A. Gemelli" and Catholic University of Rome, Rome, Italy. 9. Department of Psychiatry and Department of Rehabilitation Medicine, Amsterdam University Medical Centres (Location VUmc), Amsterdam, The Netherlands. 10. JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China. jlau@cuhk.edu.hk. 11. Department of Neurology, Shandong Provincial Hospital Affiliated To Shandong University, Jinan, Shandong, China. chengxuan.qiu@ki.se. 12. Care Sciences and Society, Department of Neurobiology, Aging Research Center, Karolinska Institutet-Stockholm University, Tomtebodavägen 18A, 171 65, Stockholm, Solna, Sweden. chengxuan.qiu@ki.se.
Abstract
PURPOSE: To investigate the associations between cardiovascular health (CVH) metrics and health-related quality of life (HRQL) among patients with ischemic stroke in China, and further explore the role of physical and cognitive function in their associations. METHODS: This hospital-based study included 1714 patients with first-ever acute ischemic stroke (age ≥ 40 years; 36.7% women) who were admitted to two university hospitals in Shandong, China. We collected information on seven CVH metrics (smoking, body mass index, diet, physical activity, blood pressure, total cholesterol, and fasting blood glucose) through interviews, clinical examinations, and laboratory tests. EQ-5D-3L was used to assess HRQL. Cognitive and physical functioning was assessed by the Montreal Cognitive Assessment test and Barthel index, respectively. Data were analyzed using the general linear regression models. RESULTS: The average score (SD) was 0.746 (0.23) for HRQL index and 72.7 (15.8) for self-rated health. Optimal levels of four individual CVH metric components (diet, physical activity, blood pressure, and blood glucose) and a higher composite CVH score were significantly associated with a greater HRQL index and better self-rated health (p < 0.05 for all). Physical dependence and cognitive impairment were associated with a lower HRQL index and poorer self-rated health status (p < 0.001). Furthermore, the relationships between CVH metrics and HRQL index varied by functional status, such that their associations were statistically significant only among people who had physical dependence or cognitive impairment. CONCLUSION: Achieving a better cardiovascular health profile is associated with better quality of life among ischemic stroke survivors, primarily in those with physical or cognitive impairment.
PURPOSE: To investigate the associations between cardiovascular health (CVH) metrics and health-related quality of life (HRQL) among patients with ischemic stroke in China, and further explore the role of physical and cognitive function in their associations. METHODS: This hospital-based study included 1714 patients with first-ever acute ischemic stroke (age ≥ 40 years; 36.7% women) who were admitted to two university hospitals in Shandong, China. We collected information on seven CVH metrics (smoking, body mass index, diet, physical activity, blood pressure, total cholesterol, and fasting blood glucose) through interviews, clinical examinations, and laboratory tests. EQ-5D-3L was used to assess HRQL. Cognitive and physical functioning was assessed by the Montreal Cognitive Assessment test and Barthel index, respectively. Data were analyzed using the general linear regression models. RESULTS: The average score (SD) was 0.746 (0.23) for HRQL index and 72.7 (15.8) for self-rated health. Optimal levels of four individual CVH metric components (diet, physical activity, blood pressure, and blood glucose) and a higher composite CVH score were significantly associated with a greater HRQL index and better self-rated health (p < 0.05 for all). Physical dependence and cognitive impairment were associated with a lower HRQL index and poorer self-rated health status (p < 0.001). Furthermore, the relationships between CVH metrics and HRQL index varied by functional status, such that their associations were statistically significant only among people who had physical dependence or cognitive impairment. CONCLUSION: Achieving a better cardiovascular health profile is associated with better quality of life among ischemic stroke survivors, primarily in those with physical or cognitive impairment.
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Authors: Thu T M Pham; Manh-Tan Vu; Thuc C Luong; Khue M Pham; Lien T K Nguyen; Minh H Nguyen; Binh N Do; Hoang C Nguyen; Tuan V Tran; Thao T P Nguyen; Hoang P Le; Cuong Q Tran; Kien T Nguyen; Shwu-Huey Yang; Chaur-Jong Hu; Chyi-Huey Bai; Tuyen Van Duong Journal: Front Med (Lausanne) Date: 2022-05-06
Authors: Rui She; Zhongrui Yan; Yanlei Hao; Zuoji Zhang; Yifeng Du; Yajun Liang; Davide L Vetrano; Joost Dekker; Bo Bai; Joseph T F Lau; Chengxuan Qiu Journal: Front Aging Neurosci Date: 2022-09-09 Impact factor: 5.702