| Literature DB >> 33929208 |
Terrence-Thang H Nguyen1, Connor J O'Brien1, Minh L N Tran1, Steven H Olson1,2, Nicholas S Settineri3, Stanley B Prusiner1,2,4, Nick A Paras1,2, Jay Conrad1,2.
Abstract
The development of a water-soluble iridium catalyst enables the trifluoromethylation of polar small molecules and peptides in DMSO solution or aqueous media. The reaction was optimized in a microtiter plate format under ambient air, using commercial Langlois reagent as a CF3 radical source, blue LEDs for excitation, and using DPBS as solvent to provide up to 60% CF3- peptide.Entities:
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Year: 2021 PMID： 33929208 DOI： 10.1021/acs.orglett.1c00871
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.072