Bruna Cestari de Azevedo1, Fernanda Mansur2, Sérgio Podgaec2. 1. Hospital Israelita Albert Einstein, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Avenida Albert Einstein, 627, Morumbi, São Paulo, CEP 05652-900, Brazil. bruna@cestari.eu. 2. Hospital Israelita Albert Einstein, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Avenida Albert Einstein, 627, Morumbi, São Paulo, CEP 05652-900, Brazil.
Abstract
INTRODUCTION: The pathogen-associated molecular patterns and the danger-associated molecular patterns are possibly responsible for the activation of the inflammatory process in endometriosis through the activation of toll-like receptors (TLRs). OBJECTIVE: The aim of this systematic review was to critically analyze the findings of published articles on TLRs in endometriosis. METHODS: The keywords used were "endometriosis" and "toll-like" and the search was performed in Pubmed, Scielo and Lilacs databases. This study followed the PRISMA guidelines and the risk of bias of articles was conducted by Newcastle-Ottawa scale (NOS). RESULTS: Overall, the studies analyzed in this review point toward an increased expression of TLRs two, four and nine in women with endometriosis. Among all TLRs, TLR4 was the most cited receptor. CONCLUSION: Despite the evidence demonstrating elevated TLR levels in endometriosis, the relationship with the disease is still unclear and needs to be clarified in further studies about innate immune response.
INTRODUCTION: The pathogen-associated molecular patterns and the danger-associated molecular patterns are possibly responsible for the activation of the inflammatory process in endometriosis through the activation of toll-like receptors (TLRs). OBJECTIVE: The aim of this systematic review was to critically analyze the findings of published articles on TLRs in endometriosis. METHODS: The keywords used were "endometriosis" and "toll-like" and the search was performed in Pubmed, Scielo and Lilacs databases. This study followed the PRISMA guidelines and the risk of bias of articles was conducted by Newcastle-Ottawa scale (NOS). RESULTS: Overall, the studies analyzed in this review point toward an increased expression of TLRs two, four and nine in women with endometriosis. Among all TLRs, TLR4 was the most cited receptor. CONCLUSION: Despite the evidence demonstrating elevated TLR levels in endometriosis, the relationship with the disease is still unclear and needs to be clarified in further studies about innate immune response.
Authors: Ahmed I Ghanem; Nadia T Khan; Meredith Mahan; Ahmed Ibrahim; Thomas Buekers; Mohamed A Elshaikh Journal: Eur J Obstet Gynecol Reprod Biol Date: 2016-12-28 Impact factor: 2.435