| Literature DB >> 33927201 |
Li-Ping Wang1, Shi-Xia Zhou2,3, Xin Wang4, Qing-Bin Lu5, Lu-Sha Shi1, Xiang Ren1, Hai-Yang Zhang3, Yi-Fei Wang1, Sheng-Hong Lin1, Cui-Hong Zhang1, Meng-Jie Geng1, Xiao-Ai Zhang3, Jun Li6, Shi-Wen Zhao7, Zhi-Gang Yi8, Xiao Chen9, Zuo-Sen Yang10, Lei Meng11, Xin-Hua Wang11, Ying-Le Liu12, Ai-Li Cui13, Sheng-Jie Lai14,15, Meng-Yang Liu3, Yu-Liang Zhu1, Wen-Bo Xu13, Yu Chen9, Jian-Guo Wu12, Zheng-Hong Yuan16, Meng-Feng Li6, Liu-Yu Huang17, Zhong-Jie Li18, Wei Liu19,20, Li-Qun Fang21,22, Huai-Qi Jing4, Simon I Hay23,24, George F Gao25, Wei-Zhong Yang25.
Abstract
National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features of the 152,792 eligible patients enrolled in this analysis. Rotavirus A and norovirus are the two leading viral pathogens detected in the patients, followed by adenovirus and astrovirus. Diarrheagenic Escherichia coli and nontyphoidal Salmonella are the two leading bacterial pathogens, followed by Shigella and Vibrio parahaemolyticus. Patients aged <5 years had higher overall positive rate of viral pathogens, while bacterial pathogens were more common in patients aged 18‒45 years. A joinpoint analysis revealed the age-specific positivity rate and how this varied for individual pathogens. Our findings fill crucial gaps of how the distributions of enteropathogens change across China in patients with diarrhea. This allows enhanced identification of the predominant diarrheal pathogen candidates for diagnosis in clinical practice and more targeted application of prevention and control measures.Entities:
Year: 2021 PMID： 33927201 DOI： 10.1038/s41467-021-22551-z
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919