Literature DB >> 33925807

Estrogens in Hepatocellular Carcinoma: Friends or Foes?

Giuseppe Carruba1.   

Abstract

Estrogens are recognized as key players in physiological regulation of various, classical and non-classical, target organs, and tissues, including liver development, homeostasis, and function. On the other hand, multiple, though dispersed, experimental evidence is highly suggestive for the implication of estrogen in development and progression of hepatocellular carcinoma. In this paper, data from our own studies and the current literature are reviewed to help understanding this apparent discrepancy.

Entities:  

Keywords:  ADAM17; FOXA; amphiregulin; aromatase; estrogen; estrogen receptors; liver; merlin

Year:  2021        PMID： 33925807     DOI： 10.3390/cancers13092085

Source DB:  PubMed          Journal:  Cancers (Basel)        ISSN： 2072-6694            Impact factor:   6.639


  89 in total

1.  Sex steroids enhance insulin receptors and glucose oxidation in Chang liver cells.

Authors:  Chandrakesan Parthasarathy; Venkatraman Natarajan Renuka; Karundevi Balasubramanian
Journal:  Clin Chim Acta       Date:  2008-09-18       Impact factor: 3.786

2.  The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis.

Authors:  Fisun Hamaratoglu; Maria Willecke; Madhuri Kango-Singh; Riitta Nolo; Eric Hyun; Chunyao Tao; Hamed Jafar-Nejad; Georg Halder
Journal:  Nat Cell Biol       Date:  2005-12-11       Impact factor: 28.824

Review 3.  An overview of evidence-based management of hepatocellular carcinoma: a meta-analysis.

Authors:  Mohammad Salhab; Ruben Canelo
Journal:  J Cancer Res Ther       Date:  2011 Oct-Dec       Impact factor: 1.805

4.  Estrogen receptors in hepatocellular carcinoma.

Authors:  N Nagasue; A Ito; H Yukaya; Y Ogawa
Journal:  Cancer       Date:  1986-01-01       Impact factor: 6.860

Review 5.  Amphiregulin: a new growth factor in hepatocarcinogenesis.

Authors:  C Berasain; J Castillo; M J Perugorría; J Prieto; M A Avila
Journal:  Cancer Lett       Date:  2007-02-26       Impact factor: 8.679

6.  The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

Authors:  R J Shaw; J G Paez; M Curto; A Yaktine; W M Pruitt; I Saotome; J P O'Bryan; V Gupta; N Ratner; C J Der; T Jacks; A I McClatchey
Journal:  Dev Cell       Date:  2001-07       Impact factor: 12.270

Review 7.  Use of tamoxifen in advanced-stage hepatocellular carcinoma. A systematic review.

Authors:  Anna K Nowak; Martin R Stockler; Pierce K H Chow; Michael Findlay
Journal:  Cancer       Date:  2005-04-01       Impact factor: 6.860

8.  Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat.

Authors:  Hua Zhang; Yuanwu Liu; Li Wang; Zhen Li; Hongwen Zhang; Jihua Wu; Nafis Rahman; Yangdong Guo; Defa Li; Ning Li; Ilpo Huhtaniemi; Suk Ying Tsang; George F Gao; Xiangdong Li
Journal:  J Lipid Res       Date:  2012-11-21       Impact factor: 5.922

9.  Estrogen receptor alpha expression and liver fibrosis in chronic hepatitis C virus genotype 1b: a clinicopathological study.

Authors:  Mustafa Cengiz; Seren Ozenirler; Guldal Yılmaz
Journal:  Hepat Mon       Date:  2014-09-24       Impact factor: 0.660

10.  Contact-dependent inhibition of EGFR signaling by Nf2/Merlin.

Authors:  Marcello Curto; Banumathi K Cole; Dominique Lallemand; Ching-Hui Liu; Andrea I McClatchey
Journal:  J Cell Biol       Date:  2007-06-04       Impact factor: 10.539
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  2 in total

1.  Acute Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy Is Associated with Placental Angiotensin-Converting Enzyme 2 Shedding.

Authors:  Elizabeth S Taglauer; Elisha M Wachman; Lillian Juttukonda; Timothy Klouda; Jiwon Kim; Qiong Wang; Asuka Ishiyama; David J Hackam; Ke Yuan; Hongpeng Jia
Journal:  Am J Pathol       Date:  2022-01-26       Impact factor: 4.307

Review 2.  Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway.

Authors:  Yusheng Guo; Guohui Wu; Junrong Yi; Qin Yang; Wengong Jiang; Shaoqiang Lin; Xiaorong Yang; Xiangsheng Cai; Liufeng Mao
Journal:  Front Oncol       Date:  2022-01-12       Impact factor: 6.244
  2 in total

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