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Literature DB >> 17308869

Effects of tumour necrosis factor-alpha on human sperm motility and apoptosis.

Anna Perdichizzi¹, Ferdinando Nicoletti, Sandro La Vignera, Nunziata Barone, Rosario D'Agata, Enzo Vicari, Aldo E Calogero, Aldo E E Calogero.

Abstract

The aim of this study was to evaluate the effects of tumour necrosis factor-alpha (TNF-alpha) on sperm motility, mitochondrial membrane potential (DeltaPsi), phosphatidylserine (PS) externalization, sperm chromatin packaging quality, and DNA fragmentation. Motile spermatozoa, obtained from 10 normozoospermic men, were incubated with increasing concentrations of TNF-alpha and analyzed 1, 3, 6, and 24 h after incubation by flow cytometry. TNF-alpha decreased total motility 24 h after incubation at 10 ng/mL and progressive motility 3 h after incubation. Accordingly, TNF-alpha reduced sperm DeltaPsi in a concentration- and time-dependent manner. TNF-alpha increased the percentage of spermatozoa with PS externalization from the concentration of 1 ng/mL 1 h after incubation. TNF-alpha produced sperm chromatin and DNA damage in a concentration- and time-dependent manner. In conclusion, these findings may explain the reduction of fertility, secondary to upregulated production of TNF-alpha, in men with urogenital infections.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17308869 DOI： 10.1007/s10875-007-9071-5

Source DB: PubMed Journal: J Clin Immunol ISSN： 0271-9142 Impact factor: 8.542

51 in total

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Authors: Izzet Koçak; Cigdem Yenisey; Mehmet Dündar; Pinar Okyay; Mukadder Serter
Journal: Urol Res Date: 2002-06-27

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28 in total

10. Infection by CagA-positive Helicobacter pylori strains may contribute to alter the sperm quality of men with fertility disorders and increase the systemic levels of TNF-alpha.

Authors: Giulia Collodel; Elena Moretti; Maria Stella Campagna; Serena Capitani; Cristina Lenzi; Natale Figura
Journal: Dig Dis Sci Date: 2009-01-22 Impact factor: 3.199

Effects of tumour necrosis factor-alpha on human sperm motility and apoptosis.

1. Apoptosis is physiologically restricted to a specialized cytoplasmic compartment in rat spermatids.

Review 2. Cell-mediated immunity in infertility.

3. [Levels of proinflammatory cytokines (Il-1 alpha, Il-6, TNF-alpha) in the semen plasma of male partners of infertile couples].

4. Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages.

5. Generation of reactive oxygen species, lipid peroxidation, and human sperm function.

Review 6. Drug insight: antagonists of tumor-necrosis factor-alpha in the treatment of inflammatory bowel disease.

Review 7. Th1 and Th2 in human diseases.

8. Relationship between seminal plasma interleukin-6 and tumor necrosis factor alpha levels with semen parameters in fertile and infertile men.

9. Fertilizing ability of sperm with unexplained in vitro fertilization failures, as assessed by the zona-free hamster egg penetration assay: its prognostic value for sperm-oolemma interaction.

10. Relationship between the presence of endogenous nicks and sperm chromatin packaging in maturing and fertilizing mouse spermatozoa.

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