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Literature DB >> 33925299

Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia.

Jana Krystofova Mike¹, Donna Marie Ferriero^1,2.

Abstract

Neonatal brain hypoxia-ischemia (HI) is a leading cause of morbidity and long-term disabilities in children. While we have made significant progress in describing HI mechanisms, the limited therapies currently offered for HI treatment in the clinical setting stress the importance of discovering new targetable pathways. Efferocytosis is an immunoregulatory and homeostatic process of clearance of apoptotic cells (AC) and cellular debris, best described in the brain during neurodevelopment. The therapeutic potential of stimulating defective efferocytosis has been recognized in neurodegenerative diseases. In this review, we will explore the involvement of efferocytosis after a stroke and HI as a promising target for new HI therapies.

Entities: Chemical Disease Gene Mutation Species

Keywords: efferocytosis; neonatal brain; stroke

Year: 2021 PMID： 33925299 DOI： 10.3390/cells10051025

Source DB: PubMed Journal: Cells ISSN： 2073-4409 Impact factor: 6.600

150 in total

1. Synaptic pruning by microglia is necessary for normal brain development.

Authors: Rosa C Paolicelli; Giulia Bolasco; Francesca Pagani; Laura Maggi; Maria Scianni; Patrizia Panzanelli; Maurizio Giustetto; Tiago Alves Ferreira; Eva Guiducci; Laura Dumas; Davide Ragozzino; Cornelius T Gross
Journal: Science Date: 2011-07-21 Impact factor: 47.728

Review 2. The role of P2Y receptors in regulating immunity and metabolism.

Authors: Marianna Lovászi; Clarissa Branco Haas; Luca Antonioli; Pál Pacher; György Haskó
Journal: Biochem Pharmacol Date: 2021-01-15 Impact factor: 5.858

3. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Authors: V A Fadok; D L Bratton; A Konowal; P W Freed; J Y Westcott; P M Henson
Journal: J Clin Invest Date: 1998-02-15 Impact factor: 14.808

4. Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification.

Authors: Camilla Lööv; Claire H Mitchell; Martin Simonsson; Anna Erlandsson
Journal: Glia Date: 2015-06-12 Impact factor: 7.452

Review 5. Phagocytic clearance in neurodegeneration.

Authors: Jennifer D Sokolowski; James W Mandell
Journal: Am J Pathol Date: 2011-04 Impact factor: 4.307

6. Brain injury after perinatal hypoxia-ischemia is exacerbated in copper/zinc superoxide dismutase transgenic mice.

Authors: J S Ditelberg; R A Sheldon; C J Epstein; D M Ferriero
Journal: Pediatr Res Date: 1996-02 Impact factor: 3.756

7. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages.

Authors: Xiurong Zhao; Guanghua Sun; Jie Zhang; Roger Strong; Weitao Song; Nicole Gonzales; James C Grotta; Jaroslaw Aronowski
Journal: Ann Neurol Date: 2007-04 Impact factor: 10.422

8. The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia.

Authors: Kimberle Shen; Harwin Sidik; William S Talbot
Journal: Cell Rep Date: 2016-01-07 Impact factor: 9.423

9. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis.

Authors: Lucy A Truman; Catriona A Ford; Marta Pasikowska; John D Pound; Sarah J Wilkinson; Ingrid E Dumitriu; Lynsey Melville; Lauren A Melrose; Carol Anne Ogden; Robert Nibbs; Gerard Graham; Christophe Combadiere; Christopher D Gregory
Journal: Blood Date: 2008-09-17 Impact factor: 22.113

Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia.

1. Synaptic pruning by microglia is necessary for normal brain development.

Review 2. The role of P2Y receptors in regulating immunity and metabolism.

3. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

4. Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification.

Review 5. Phagocytic clearance in neurodegeneration.

6. Brain injury after perinatal hypoxia-ischemia is exacerbated in copper/zinc superoxide dismutase transgenic mice.

7. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages.

8. The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia.

9. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis.

Review 10. The physiology of foamy phagocytes in multiple sclerosis.

Review 1. Microglia as the Critical Regulators of Neuroprotection and Functional Recovery in Cerebral Ischemia.

Review 2. The role of efferocytosis in neuro-degenerative diseases.

Review 3. Efferocytosis in the Central Nervous System.

Review 4. The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives.