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Literature DB >> 33924772

From Channels to Canonical Wnt Signaling: A Pathological Perspective.

Silvia Muccioli¹, Valentina Brillo¹, Leonardo Chieregato¹, Luigi Leanza¹, Vanessa Checchetto¹, Roberto Costa¹.

Abstract

Wnt signaling is an important pathway mainly active during embryonic development and controlling cell proliferation. This regulatory pathway is aberrantly activated in several human diseases. Ion channels are known modulators of several important cellular functions ranging from the tuning of the membrane potential to modulation of intracellular pathways, in particular the influence of ion channels in Wnt signaling regulation has been widely investigated. This review will discuss the known links between ion channels and canonical Wnt signaling, focusing on their possible roles in human metabolic diseases, neurological disorders, and cancer.

Entities: Chemical Disease Gene Species

Keywords: Wnt signaling; cancer; ion channels; metabolic diseases; neurological disorders

Year: 2021 PMID： 33924772 DOI： 10.3390/ijms22094613

Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923

74 in total

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Authors: Danette L Daniels; William I Weis
Journal: Nat Struct Mol Biol Date: 2005-03-13 Impact factor: 15.369

2. A Critical Role for β-Catenin in Modulating Levels of Insulin Secretion from β-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization.

Authors: Brie Sorrenson; Emmanuelle Cognard; Kathryn L Lee; Waruni C Dissanayake; Yanyun Fu; Weiping Han; William E Hughes; Peter R Shepherd
Journal: J Biol Chem Date: 2016-10-24 Impact factor: 5.157

3. Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation.

Authors: Raphael Rapetti-Mauss; Viviana Bustos; Warren Thomas; Jean McBryan; Harry Harvey; Natalia Lajczak; Stephen F Madden; Bernard Pellissier; Franck Borgese; Olivier Soriani; Brian J Harvey
Journal: Proc Natl Acad Sci U S A Date: 2017-04-03 Impact factor: 11.205

Review 4. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion.

Authors: R Kemler
Journal: Trends Genet Date: 1993-09 Impact factor: 11.639

5. Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling.

Authors: Ilaria Zancan; Stefania Bellesso; Roberto Costa; Marika Salvalaio; Marina Stroppiano; Chrissy Hammond; Francesco Argenton; Mirella Filocamo; Enrico Moro
Journal: Hum Mol Genet Date: 2014-10-17 Impact factor: 6.150

6. Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways.

Authors: Christopher Thrasivoulou; Michael Millar; Aamir Ahmed
Journal: J Biol Chem Date: 2013-10-24 Impact factor: 5.157

Review 7. T cell exhaustion: from pathophysiological basics to tumor immunotherapy.

Authors: Kemal Catakovic; Eckhard Klieser; Daniel Neureiter; Roland Geisberger
Journal: Cell Commun Signal Date: 2017-01-05 Impact factor: 5.712

8. Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells.

Authors: Qing-Ling Zhang; De-De Lian; Ming Ji Zhu; Xue Mei Li; Jae Kyung Lee; Tae-Jin Yoon; Jeung-Hoon Lee; Ri-Hua Jiang; Chang Deok Kim
Journal: Biomed Res Int Date: 2019-06-09 Impact factor: 3.411

9. Silencing of KCNA1 suppresses the cervical cancer development via mitochondria damage.

Authors: Li Liu; Yumei Chen; Qingyuan Zhang; Changzhong Li
Journal: Channels (Austin) Date: 2019-12 Impact factor: 2.581

10. Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma.

Authors: Angela Zaccagnino; Antonella Managò; Luigi Leanza; Artur Gontarewitz; Bernhard Linder; Michele Azzolini; Lucia Biasutto; Mario Zoratti; Roberta Peruzzo; Karen Legler; Anna Trauzold; Holger Kalthoff; Ildiko Szabo
Journal: Oncotarget Date: 2017-06-13

3 in total